An FSP1 inhibitor and ferroptosis enhancer
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NPD4928

Item No. 36598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(9,10-dihydro-3,4,8,8-tetramethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b′]dipyran-5-yl)oxy]-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-acetamide
CAS Number
956965-61-0
Molecular Formula
C29H32N2O6
Formula Weight
504.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(O1)C(C)=C(C)C2=C1C3=C(C=C2OCC(NCCC4=CNC5=C4C=C(OC)C=C5)=O)OC(C)(C)CC3
InChi Code
InChI=1S/C29H32N2O6/c1-16-17(2)28(33)36-27-20-8-10-29(3,4)37-23(20)13-24(26(16)27)35-15-25(32)30-11-9-18-14-31-22-7-6-19(34-5)12-21(18)22/h6-7,12-14,31H,8-11,15H2,1-5H3,(H,30,32)
InChi Key
ZDCXTKTVNQLRGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $216

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    10 mg

    $378

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    25 mg

    $539

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    Cayman Chemical
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    Product Description

    NPD4928 is an inhibitor of ferroptosis suppressor protein 1 (FSP1) and an enhancer of ferroptosis.1 It binds to FSP1 and inhibits its activity in a cell-free NADH consumption assay. NPD4928 (3 µM) enhances cytotoxicity induced by the ferroptosis inducer RSL3 (Item No. 19288) in PANC-1 prostate cancer cells in a synergistic manner. It also enhances cytotoxicity induced by sulfasalazine (Item No. 15025) and L-buthionine sulfoximine (BSO) in the same cells. NPD4928 in combination with RSL3 induces cytotoxicity in PC3, MKN74, DU145, MIA PaCa-2, and A549 cancer cells (IC50s = 105, 95, 103, 140, and 155 nM, respectively) but not BxPC-3 or RPMI-8226 cancer cells (IC50s = >30 µM for both).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshioka, H., Kawamura, T., Muroi, M., et al. Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1). ACS Chem Biol. 17(2), 483-491 (2022).