An inhibitor of prostaglandin F synthase/AKR1C3
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CRT0036521

Item No. 36600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(3,4-dihydro-2(1H)-isoquinolinyl)sulfonyl]-benzoic acid
CAS Number
327092-81-9
Molecular Formula
C16H15NO4S
Formula Weight
317.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 25 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.25 mg/ml
SMILES
O=C(C1=CC=CC(S(=O)(N2CC3=C(CC2)C=CC=C3)=O)=C1)O
InChi Code
InChI=1S/C16H15NO4S/c18-16(19)13-6-3-7-15(10-13)22(20,21)17-9-8-12-4-1-2-5-14(12)11-17/h1-7,10H,8-9,11H2,(H,18,19)
InChi Key
ZGVIUMKHTXKKOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $32

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    100 mg

    $61

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    250 mg

    $165

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    500 mg

    $248

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    Product Description

    CRT0036521 is an inhibitor of prostaglandin F synthase, also known as aldo-keto reductase 1C3 (AKR1C3; IC50 = 0.013 µM).1 It is selective for prostaglandin F synthase/AKR1C3 over AKR1C1, AKR1C2, and AKR1C4 (IC50s = 20, >30, and >30 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jamieson, S.M.F., Brooke, D.G., Heinrich, D., et al. 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids: Highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. J. Med. Chem. 55(17), 7746-7758 (2012).