An inhibitor of survivin
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LQZ-7I

Item No. 36602

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2,N3-bis(4-fluorophenyl)-2,3-quinoxalinediamine
CAS Number
195822-23-2
Molecular Formula
C20H14F2N4
Formula Weight
348.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
244, 270 nm
SMILES
FC1=CC=C(NC2=NC3=C(N=C2NC4=CC=C(C=C4)F)C=CC=C3)C=C1
InChi Code
InChI=1S/C20H14F2N4/c21-13-5-9-15(10-6-13)23-19-20(24-16-11-7-14(22)8-12-16)26-18-4-2-1-3-17(18)25-19/h1-12H,(H,23,25)(H,24,26)
InChi Key
DKPCKOKYSVPFEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $185

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    50 mg

    $351

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    100 mg

    $663

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    250 mg

    $1,289

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    Cayman Chemical
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    Product Description

    LQZ-7I is an inhibitor of survivin.1 It inhibits survivin dimerization in a secreted alkaline phosphatase (SEAP) assay using DU145 prostate cancer cells expressing survivin and induces survivin degradation in C4-2 and PC3 prostate cancer cells in a proteasome-dependent manner. LQZ-7I is cytotoxic to C4-2 and PC3 cells (IC50s = 3.1 and 4.8 µM, respectively). It reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 100 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peery, R., Kyei-Baffour, K., Dong, Z., et al. Synthesis and identification of a novel lead targeting survivin dimerization for proteasome-dependent degradation. J. Med. Chem. 63(13), 7243-7251 (2020).