A deuterated derivative of L-838,417
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Unlabeled Version(s)
22007L-838,417
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CTP354

Item No. 36618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2,5-difluorophenyl)-7-[1,1-di(methyl-d3)ethyl-2,2,2-d3]-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
CAS Number
1213669-91-0
Molecular Formula
C19H10D9F2N7O
Formula Weight
408.5
Purity
≥99% (deutereated forms d1-d9)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
λmax
248 nm
SMILES
CN1C(COC2=NN3C(C4=C(C=CC(F)=C4)F)=NN=C3C=C2C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=NC=N1
InChi Code
InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3/i1D3,2D3,3D3
InChi Key
BQDUNOMMYOKHEP-GQALSZNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $147

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    25 mg

    $290

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    50 mg

    $499

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    Product Description

    CTP354 is a deuterated derivative of the GABAA receptor modulator L-838,417.1 It binds to the GABAA receptor benzodiazepine binding site in non-α1 subunit-containing GABAA receptors. CTP354 has a longer duration of action than L-838,417 in a rat model of neuropathic pain induced by sciatic nerve ligation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harbeson, S.L., and Tung, R.D. Deuterium medicinal chemistry: A new approach to drug discovery and development. Medchem News 24(2), 8-22 (2014).