An iron uptake inhibitor
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Ferristatin II

Item No. 36621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3-[2-[4′-[2-(2,4-diaminophenyl)diazenyl][1,1′-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-(2-phenyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt
CAS Number
1937-37-7
Synonyms
  • Chlorazol Black
  • C.I. 30235
  • NSC 8679
Molecular Formula
C34H25N9O7S2 • 2Na
Formula Weight
781.7
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
596 nm
SMILES
O=S([O-])(C1=CC2=CC(S(=O)([O-])=O)=C(C(N)=C2C(O)=C1N=NC3=CC=CC=C3)N=NC4=CC=C(C5=CC=C(N=NC6=CC=C(C=C6N)N)C=C5)C=C4)=O.[Na+].[Na+]
InChi Code
InChI=1S/C34H27N9O7S2.2Na/c35-22-10-15-27(26(36)18-22)41-38-24-11-6-19(7-12-24)20-8-13-25(14-9-20)40-42-32-28(51(45,46)47)16-21-17-29(52(48,49)50)33(34(44)30(21)31(32)37)43-39-23-4-2-1-3-5-23;;/h1-18,44H,35-37H2,(H,45,46,47)(H,48,49,50);;/q;2*+1/p-2
InChi Key
XRPLBRIHZGVJIC-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $32

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    25 g

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    50 g

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    100 g

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    Product Description

    Ferristatin II is an inhibitor of iron uptake.1 It inhibits iron uptake (IC50 = ~12 µM), as well as induces degradation of transferrin receptor protein 1 (TfR1), an effect that can be reversed by the lipid membrane disruptor nystatin, in HeLa cells. In vivo ferristatin II (0.2, 10, and 40 mg/kg) reduces serum iron levels and transferrin saturation in rats. It also suppresses traumatic brain injury-induced lipid peroxidation, neuronal apoptosis, and the number of cortical iron deposits in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Byrne, S.L., Buckett, P.D., Kim, J., et al. Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo. PLoS One 8(7), e70199 (2013).

    2. Cheng, Y., Qu, W., Li, J., et al. Ferristatin II, an iron uptake inhibitor, exerts neuroprotection against traumatic brain injury via suppressing ferroptosis. ACS Chem. Neurosci. 13(5), 664-675 (2022).