An inhibitor of glutathione reductase and thioredoxin reductase
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LCS3

Item No. 36636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-5-nitro-2-furancarboxamide
CAS Number
109844-92-0
Molecular Formula
C11H7ClN2O4
Formula Weight
266.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: SlightlyDMSO: 1 mg/ml
λmax
251, 318 nm
SMILES
O=C(NC1=CC=C(Cl)C=C1)C=2OC(=CC2)N(=O)=O
InChi Code
InChI=1S/C11H7ClN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
InChi Key
JDBZJNUHQINERI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $172

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    10 mg

    $324

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    Cayman Chemical
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    Product Description

    LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR; IC50s = 3.3 and 3.8 µM, respectively).1 It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells. It is also active against M. tuberculosis (MIC = 0.098 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, F.D., Ferrarone, J., Liu, A., et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 38(6), 110343 (2022).

    2. Gallardo-Marcias, R., Kumar, P., Jaskowski, M., et al. Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent. Bioorg. Med. Chem. Lett. 29(4), 601-606 (2019).