A mitochondrial complex I inhibitor
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BAY-179

Item No. 36657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[4-(2-benzofuranyl)-2-thiazolyl]-1-piperidinyl]methyl]-3H-imidazo[4,5-b]pyridine
CAS Number
2764880-87-5
Molecular Formula
C23H21N5OS
Formula Weight
415.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly soluble
λmax
286, 310 nm
SMILES
C12=NC=CC=C1NC(CN3CCC(C4=NC(C5=CC6=C(C=CC=C6)O5)=CS4)CC3)=N2
InChi Code
InChI=1S/C23H21N5OS/c1-2-6-19-16(4-1)12-20(29-19)18-14-30-23(26-18)15-7-10-28(11-8-15)13-21-25-17-5-3-9-24-22(17)27-21/h1-6,9,12,14-15H,7-8,10-11,13H2,(H,24,25,27)
InChi Key
JOCPQSJABURDDD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Product Description

    BAY-179 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50s = 79, 38, 27, and 47 nM for the human, mouse, rat, and dog enzymes, respectively).1 See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mowat, J., Ehrmann, A.H.M., Christian, S., et al. Identification of the highly active, species cross-reactive complex I inhibitor BAY-179. ACS Med. Chem. Lett. 13(3), 348-357 (2022).