A prodrug form of furamidine
Related Products
Active Metabolite(s)
19121Furamidine (hydrochloride)
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Pafuramidine

Item No. 36669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-(2,5-furandiyl)bis[N-methoxy-benzenecarboximidamide
CAS Number
186953-56-0
Synonyms
  • DB289
Molecular Formula
C20H20N4O3
Formula Weight
364.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble (heated)
SMILES
N=C(NOC)C(C=C1)=CC=C1C2=CC=C(C3=CC=C(C(NOC)=N)C=C3)O2
InChi Code
InChI=1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)
InChi Key
UKOQVLAXCBRRGH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $66

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    1 mg

    $112

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    Cayman Chemical
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    Product Description

    Pafuramidine is a prodrug form of the protein arginine methyltransferase 1 (PRMT1) inhibitor furamidine (Item No. 19121).1 Oral administration of pafuramidine (25 mg/kg per day), in combination with the antiprotozoal benznidazole (Item No. 29090), reduces the number of circulating parasites and increases survival in a mouse model of T. cruzi infection.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boykin, D.W., Kumar, A., Hall, J.E., et al. Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs. Bioorganic Med. Chem. Lett. 6(24), 3017-3020 (1996).

    2. de Gama Jaén Batista, D., Batista, M.M., de Oliveira, G.M., et al. Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo. PLoS One 6(7), e22155 (2011).