An α2-AR agonist
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Analytical Standard(s)
38581Romifidine (hydrochloride)
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Romifidine (hydrochloride)

Item No. 36693

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride
CAS Number
65896-14-2
Synonyms
  • STH 2130
Molecular Formula
C9H9BrFN3 • HCl
Formula Weight
294.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
BrC1=CC=CC(F)=C1NC2=NCCN2.Cl
InChi Code
InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChi Key
SDXVSIWCVTYYQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $76

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    10 mg

    $137

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    25 mg

    $285

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    50 mg

    $494

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    Product Description

    Romifidine is an α2-adrenergic receptor (α2-AR) agonist.1 Epidural administration of romifidine (50 µg/kg) induces antinociception and sedation in donkeys. It also induces bradycardia in horses when administered at doses ranging from 0.04 to 0.12 mg/kg.2 Formulations containing romifidine have been used as veterinary sedatives. This product is also available as an analytical reference standard (Item No. 38581).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marzok, M., Almubarak, A.I., Babiker, H., et al. Comparative evaluation of sedative and anti-nociceptive effects of epidural romifidine, romifidine-lidocaine, and lidocaine in donkeys (Equus asinus). Front. Vet. Sci. 9, 966715 (2022).

    2. Gasthuys, F., Parmentier, D., Goossens, L., et al. A preliminary study on the effects of atropine sulphate on bradycardia and heart blocks during romifidine sedation in the horse. Vet. Res. Commun. 14(6), 489-502 (1990).