A peptide inhibitor of the 14-3-3-Raf-1 protein-protein interaction
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
Cell Signaling

R18 (trifluoroacetate salt)

Item No. 36695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-α-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-leucyl-L-α-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline, trifluoroacetate salt
Molecular Formula
C101H157N27O29S3 • XCF3COOH
Formula Weight
2309.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
PHCVPRDLSWLDLEANMCLP-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC(C)C)NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]2N(C([C@@H](NC([C@H](CS)NC([C@H](CC3=CN=CN3)NC(C4CCCN4)=O)=O)=O)C(C)C)=O)CCC2)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C101H157N27O29S3.C2HF3O2/c1-48(2)33-62(86(142)111-60(25-26-77(131)132)83(139)110-53(11)81(137)114-67(39-76(102)130)91(147)112-61(27-32-160-12)85(141)124-72(45-158)95(151)122-70(36-51(7)8)98(154)128-31-18-24-75(128)100(156)157)116-93(149)69(41-79(135)136)121-87(143)63(34-49(3)4)115-89(145)65(37-54-42-108-57-20-14-13-19-56(54)57)118-94(150)71(44-129)123-88(144)64(35-50(5)6)117-92(148)68(40-78(133)134)120-84(140)59(22-16-29-107-101(103)104)113-97(153)74-23-17-30-127(74)99(155)80(52(9)10)126-96(152)73(46-159)125-90(146)66(38-55-43-105-47-109-55)119-82(138)58-21-15-28-106-58;3-2(4,5)1(6)7/h13-14,19-20,42-43,47-53,58-75,80,106,108,129,158-159H,15-18,21-41,44-46H2,1-12H3,(H2,102,130)(H,105,109)(H,110,139)(H,111,142)(H,112,147)(H,113,153)(H,114,137)(H,115,145)(H,116,149)(H,117,148)(H,118,150)(H,119,138)(H,120,140)(H,121,143)(H,122,151)(H,123,144)(H,124,141)(H,125,146)(H,126,152)(H,131,132)(H,133,134)(H,135,136)(H,156,157)(H4,103,104,107);(H,6,7)/t53-,58?,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,80-;/m0./s1
InChi Key
RLMYFUMCZYJMNX-UCEOJSLQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $197

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    5 mg

    $737

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    Product Description

    R18 is a synthetic peptide inhibitor of the protein-protein interaction between 14-3-3 proteins and Raf-1.1 It binds to 14-3-3τ, -β, and -ζ (Kds = 7.1, 7, and 8.9 nM, respectively) and inhibits 14-3-3τ binding to Raf-1 in a filter binding assay when used at a concentration of 5 nM. R18 also inhibits 14-3-3ζ-mediated protection of Raf-1 from phosphatase-induced inactivation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang B, Yang H, Liu Y.C., et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry 38(38), 12499-12504 (1999).