A branched-chain ionizable cationic lipidoid
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306Oi10

Item No. 36698

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
CAS Number
2322290-93-5
Molecular Formula
C59H115N3O8
Formula Weight
994.6
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O=C(CCN(CCCN(CCCN(CCC(OCCCCCCCC(C)C)=O)CCC(OCCCCCCCC(C)C)=O)C)CCC(OCCCCCCCC(C)C)=O)OCCCCCCCC(C)C
InChi Code
InChI=1S/C59H115N3O8/c1-52(2)32-22-14-10-18-26-48-67-56(63)36-44-61(45-37-57(64)68-49-27-19-11-15-23-33-53(3)4)42-30-40-60(9)41-31-43-62(46-38-58(65)69-50-28-20-12-16-24-34-54(5)6)47-39-59(66)70-51-29-21-13-17-25-35-55(7)8/h52-55H,10-51H2,1-9H3
InChi Key
BPPZRZOKGADTQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $116

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    10 mg

    $220

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    25 mg

    $376

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    Cayman Chemical
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    Product Description

    306Oi10 is a branched-chain ionizable cationic lipidoid (pKa = 6.4) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing 306Oi10 and encapsulating an mRNA reporter increase luminescence in the livers and spleens in mice to a greater extent than LNPs containing MC3 (DLin-MC3-DMA; Item No. 34364) or C12-200 (Item No. 36699).2 LNPs containing 306Oi10 and encapsulating an mRNA reporter selectively accumulate in hepatocytes, and to a lesser extent in Kupffer and endothelial cells, in mice. LNPs containing 306Oi10 and encapsulating mRNA encoding erythropoietin (EPO) increase serum levels of EPO in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hajj, K.A., Ball, R.L., Deluty, S.B., et al. Branched-tail lipid nanoparticles potently deliver mRNA in vivo due to enhanced ionization at endosomal pH. Small 15(6), e1805097 (2019).

    2. Morgan, B.J., Dey, S., Johnson, S.W., et al. Design, synthesis, and investigation of protein kinase C inhibitors: Total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J. Am. Chem. Soc. 131(26), 9413-9425 (2009).