A stearoyl-CoA desaturase inhibitor
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GSK1940029

Item No. 36704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3,4-dichlorophenyl)methyl]-N-[4-(hydroxymethyl)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide
CAS Number
1150701-66-8
Molecular Formula
C18H16Cl2N4O2
Formula Weight
391.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
268 nm
SMILES
CC1=C(C(NC2=CC=C(CO)C=C2)=O)N=NN1CC3=CC(Cl)=C(Cl)C=C3
InChi Code
InChI=1S/C18H16Cl2N4O2/c1-11-17(18(26)21-14-5-2-12(10-25)3-6-14)22-23-24(11)9-13-4-7-15(19)16(20)8-13/h2-8,25H,9-10H2,1H3,(H,21,26)
InChi Key
QQRGSFYTPBYCFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $85

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    10 mg

    $156

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    25 mg

    $281

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    Product Description

    GSK1940029 is a stearoyl-CoA desaturase (SCD) inhibitor.1 It increases palmitate-induced phosphorylation of p70 ribosomal S6 kinase 1 (p70S6K1) and lactate dehydrogenase (LDH) release from AML12 hepatocytes when used at a concentration of 20 µM.2 GSK1940029 (10 µM) also increases palmitate-induced increases in extracellular and intracellular triglyceride levels in AML12 hepatocytes, an effect that can be reversed by the mammalian target of rapamycin (mTOR) inhibitor torin 1 (Item No. 10997).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bouillot, A.M.J., Laroze, A., and Trottet, L. 1,2,3-triazole derivatives for use as stearoyl-coa desaturase inhibitors. (2009).

    2. Wang, J., Chen, Y., Song, Q., et al. mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes. Exp. Biol. Med. (Maywood) 245(14), 1268-1279 (2020).