A cationic cell-penetrating peptide
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Product Type

Biochemicals
Peptides

Research Area

Neuroscience
Neuroprotection

(Arg)9 (trifluoroacetate salt)

Item No. 36714

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginine, 2,2,2-trifluoroacetate
CAS Number
1228255-42-2
Synonyms
  • Nona-Arginine
  • Poly-Arginine-9
  • RRRRRRRRR
Molecular Formula
C54H110N36O10 • XCF3COOH
Formula Weight
1423.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solublePBS (pH 7.2): 5 mg/ml
SMILES
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C54H110N36O10.C2HF3O2/c55-28(10-1-19-74-46(56)57)37(91)83-29(11-2-20-75-47(58)59)38(92)84-30(12-3-21-76-48(60)61)39(93)85-31(13-4-22-77-49(62)63)40(94)86-32(14-5-23-78-50(64)65)41(95)87-33(15-6-24-79-51(66)67)42(96)88-34(16-7-25-80-52(68)69)43(97)89-35(17-8-26-81-53(70)71)44(98)90-36(45(99)100)18-9-27-82-54(72)73;3-2(4,5)1(6)7/h28-36H,1-27,55H2,(H,83,91)(H,84,92)(H,85,93)(H,86,94)(H,87,95)(H,88,96)(H,89,97)(H,90,98)(H,99,100)(H4,56,57,74)(H4,58,59,75)(H4,60,61,76)(H4,62,63,77)(H4,64,65,78)(H4,66,67,79)(H4,68,69,80)(H4,70,71,81)(H4,72,73,82);(H,6,7)/t28-,29-,30-,31-,32-,33-,34-,35-,36-;/m0./s1
InChi Key
XGQPDCDNEZIVKJ-MXIXLHBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $94

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    5 mg

    $440

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    10 mg

    $834

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    25 mg

    $1,505

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    Product Description

    (Arg)9 is a cationic cell-penetrating peptide.1,2 It has been used to deliver various cargo to cells, including fluorescent proteins and plasmids. (Arg)9 (5 and 10 µM) also protects primary rat cortical neurons from glutamate-induced excitotoxicity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, M., Chou, J.-C., and Lee, H.-J. Cellular internalization of fluorescent proteins via arginine-rich intracellular delivery peptide in plant cells. Plant Cell Physiol. 46(3), 482-488 (2005).

    2. Lee, C.-Y., Li, J.-F., Liou, J.-S., et al. A gene delivery system for human cells mediated by both a cell-penetrating peptide and a piggyBac transposase. Biomaterials 32(26), 6264-6276 (2011).

    3. Meloni, B.P., Brookes, L.M., Clark, V.W., et al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J. Cereb. Blood Flow Metab. 35(6), 993-1004 (2015).