A neuropeptide and an NPY receptor agonist
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Neuropeptide Y (porcine, bovine) (trifluoroacetate salt)

Item No. 36715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-prolyl-L-seryl-L-lysyl-L-prolyl-L-α-aspartyl-L-asparaginyl-L-prolylglycyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-prolyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-leucyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl- L-tyrosinamide, trifluoroacetate salt
Synonyms
  • NPY (porcine, bovine)
Molecular Formula
C190H287N55O57 • XCF3COOH
Formula Weight
4253.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
[H]NCCCC[C@H](NC([C@H](CO)NC([C@@H]1CCCN1C([C@H](CC2=CC=C(O)C=C2)N[H])=O)=O)=O)C(N3CCC[C@H]3C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N4CCC[C@H]4C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C=C6)=CC=C6O)C(N[C@@H](CC(C=C7)=CC=C7O)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CNC=N8)C(N[C@@H](CC(C=C9)=CC=C9O)C(N[C@@](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@](C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C=C%10)=CC=C%10O)C(N)=O)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)CC(C)C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)CC(C)C)=O)C)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C190H287N55O57.C2HF3O2/c1-16-94(9)149(180(296)235-129(81-141(194)255)169(285)227-124(74-93(7)8)172(288)240-150(95(10)17-2)181(297)241-151(100(15)248)182(298)222-116(32-23-67-209-190(203)204)156(272)221-118(57-60-140(193)254)161(277)219-114(30-21-65-207-188(199)200)157(273)224-121(152(196)268)76-102-39-49-108(250)50-40-102)239-173(289)127(79-105-45-55-111(253)56-46-105)230-168(284)128(80-106-86-205-90-211-106)231-159(275)115(31-22-66-208-189(201)202)220-165(281)123(73-92(5)6)225-155(271)97(12)213-174(290)134(88-246)237-167(283)126(78-104-43-53-110(252)54-44-104)229-166(282)125(77-103-41-51-109(251)52-42-103)228-158(274)113(29-20-64-206-187(197)198)217-153(269)96(11)212-163(279)122(72-91(3)4)226-170(286)131(84-147(264)265)233-162(278)119(59-62-145(260)261)218-154(270)98(13)214-177(293)137-34-25-68-242(137)183(299)99(14)215-164(280)130(83-146(262)263)232-160(276)117(58-61-144(258)259)216-143(257)87-210-176(292)136-33-24-70-244(136)186(302)133(82-142(195)256)236-171(287)132(85-148(266)267)234-178(294)139-36-27-71-245(139)185(301)120(28-18-19-63-191)223-175(291)135(89-247)238-179(295)138-35-26-69-243(138)184(300)112(192)75-101-37-47-107(249)48-38-101;3-2(4,5)1(6)7/h37-56,86,90-100,112-139,149-151,246-253H,16-36,57-85,87-89,191-192H2,1-15H3,(H2,193,254)(H2,194,255)(H2,195,256)(H2,196,268)(H,205,211)(H,210,292)(H,212,279)(H,213,290)(H,214,293)(H,215,280)(H,216,257)(H,217,269)(H,218,270)(H,219,277)(H,220,281)(H,221,272)(H,222,298)(H,223,291)(H,224,273)(H,225,271)(H,226,286)(H,227,285)(H,228,274)(H,229,282)(H,230,284)(H,231,275)(H,232,276)(H,233,278)(H,234,294)(H,235,296)(H,236,287)(H,237,283)(H,238,295)(H,239,289)(H,240,288)(H,241,297)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H4,197,198,206)(H4,199,200,207)(H4,201,202,208)(H4,203,204,209);(H,6,7)/t94-,95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,149-,150-,151-;/m0./s1
InChi Key
IGEZIIGYHHEFBI-ZWYMSMRWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Neuropeptide Y (NPY) is a neuropeptide involved in appetite, vasoconstriction, cardiac contractility, and intestinal secretion and an agonist of the NPY receptors Y1, Y2, and Y5.1,2 It is expressed throughout the body.1 NPY selectively inhibits forskolin-induced cAMP accumulation in L-M(TK-) cells expressing rat Y1 or Y2 and HEK293 cells expressing rat Y5 over L-M(TK-) cells expressing rat Y4 receptors (EC50s = 0.15, 2.7, 0.66, and >1,000 nM, respectively).2 It increases perfusion pressure in isolated guinea pig heart (EC30 = 1.3 nM).3 Intracerebroventricular administration of NPY (300 pmol/animal) increases food intake in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balasubramaniam, A. Neuropeptide Y family of hormones: Receptor subtypes and antagonists. Peptides 18(3), 445-457 (1997).

    2. Gerald, C., Walker, M.W., Criscione, L., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382(6587), 168-171 (1996).

    3. Rioux, F., Bachelard, H., Martel, J.-C., et al. The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea pig isolated heart. Peptides 7(1), 27-31 (1986).