A synthetic peptide derivative of vasopressin
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Ornipressin (acetate)

Item No. 36716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-L-ornithine-vasopressin, acetate
CAS Number
914453-98-8
Synonyms
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2
  • 8-Ornithine Vasopressin
  • Orn8-Vasopressin
  • POR-8
Molecular Formula
C45H63N13O12S2 • XC2H4O2
Formula Weight
1042.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
CYFQNCPXG-NH2 where X = ornithine
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 20 mg/ml
SMILES
OC1=CC=C(C[C@H](NC([C@@H](N)CSSC[C@@H](C(N2CCC[C@H]2C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O)=O)NC3=O)=O)C(N[C@H](C(N[C@H](C(N[C@H]3CC(N)=O)=O)CCC(N)=O)=O)CC4=CC=CC=C4)=O)C=C1.CC(O)=O
InChi Code
InChI=1S/C45H63N13O12S2.C2H4O2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33;1-2(3)4/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
InChi Key
AYJSELDHDXYDKX-HPILINOVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $108

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    10 mg

    $205

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    25 mg

    $486

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    50 mg

    $917

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    Product Description

    Ornipressin is an agonist of the vasopressin V1A receptor and a synthetic peptide derivative of argipressin (Item No. 24154) containing an arginine-to-ornithine substitution at position eight.1 It selectively induces reporter gene expression in HEK293 cells expressing vasopressin V1A and V2 receptors (EC50s = 0.69 and 0.45 nM, respectively, for the human receptors) over cells expressing vasopressin V1B receptors.2 It is selective for vasopressin V1A and V2 receptors over the vasopressin V1B receptor and oxytocin receptor (EC50s = 7.5 and 71 nM, respectively, for the human receptors). Ornipressin increases arterial blood pressure in rats when administered at a dose of 0.1 nmol/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kam, P.C.A., and Tay, T.M. The pharmacology of ornipressin (POR-8): A local vasoconstrictor used in surgery. Eur. J. Anaesthesiol. 15(2), 133-139 (1998).

    2. Wisniewski, K., Galyean, R., Tariga, H., et al. New, potent, selective, and short-acting peptidic V1a receptor agonists. J. Med. Chem. 54(13), 4388-4398 (2011).