An antibacterial peptide
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PR 39 Peptide (porcine) (trifluoroacetate salt)

Item No. 36717

Product Insert (PDF)
Technical Information
Synonyms
  • Antibacterial Protein PR 39 (131-169)
  • Proline-arginine-rich 39 peptide (131-169)
Molecular Formula
C229H346N70O40 • XCF3COOH
Formula Weight
4719.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2
Solubility(Learn about Variance in Solubility)
Water: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C([C@H](CCCNC(N)=N)N[H])N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@@H](CC(C=C4)=CC=C4O)C(N[C@H](C(N5CCC[C@H]5C(N[C@@H](CCCNC(N)=N)C(N6CCC[C@H]6C(N[C@@H](CCCNC(N)=N)C(N7CCC[C@H]7C(N8CCC[C@H]8C(N9CCC[C@H]9C(N[C@H](C(N[C@H](C(N%10CCC[C@H]%10C(N%11CCC[C@H]%11C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N%12CCC[C@H]%12C(N%13CCC[C@H]%13C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N%14CCC[C@H]%14C(N%15CCC[C@H]%15C(NCC(N[C@H](C(N%16CCC[C@H]%16C(N%17CCC[C@H]%17C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N%18CCC[C@H]%18C(N%19CCC[C@H]%19C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N%20CCC[C@H]%20C(N)=O)=O)CC%21=CC=CC=C%21)=O)=O)=O)=O)CC%22=CC=CC=C%22)=O)=O)=O)=O)CC%23=CC=CC=C%23)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC%24=CC=CC=C%24)=O)CC%25=CC=CC=C%25)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C229H346N70O40.C2HF3O2/c1-7-135(6)181(219(339)299-123-51-90-179(299)217(337)285-109-34-73-162(285)191(311)262-132-180(301)263-157(128-137-54-15-9-16-55-137)207(327)295-119-47-85-174(295)213(333)286-110-38-78-167(286)193(313)267-147(66-27-99-256-224(240)241)187(307)278-159(130-139-58-19-11-20-59-139)209(329)296-120-48-86-175(296)214(334)288-112-40-79-168(288)194(314)266-146(65-26-98-255-223(238)239)186(306)277-158(129-138-56-17-10-18-57-138)208(328)281-105-33-72-161(281)182(231)302)280-188(308)148(67-28-100-257-225(242)243)268-195(315)169-80-41-113-289(169)212(332)173-84-46-118-294(173)206(326)156(125-134(4)5)275-185(305)145(64-25-97-254-222(236)237)265-192(312)166-77-39-111-287(166)215(335)176-87-49-121-297(176)210(330)160(131-140-60-21-12-22-61-140)279-190(310)153(126-136-52-13-8-14-53-136)273-199(319)171-82-43-115-291(171)216(336)178-89-50-122-298(178)218(338)177-88-45-117-293(177)204(324)152(71-32-104-261-229(250)251)272-197(317)164-75-36-107-283(164)202(322)150(69-30-102-259-227(246)247)270-198(318)165-76-37-108-284(165)205(325)155(124-133(2)3)276-189(309)154(127-141-91-93-142(300)94-92-141)274-200(320)170-81-42-114-290(170)211(331)172-83-44-116-292(172)203(323)151(70-31-103-260-228(248)249)271-196(316)163-74-35-106-282(163)201(321)149(68-29-101-258-226(244)245)269-184(304)144(63-24-96-253-221(234)235)264-183(303)143(230)62-23-95-252-220(232)233;3-2(4,5)1(6)7/h8-22,52-61,91-94,133-135,143-179,181,300H,7,23-51,62-90,95-132,230H2,1-6H3,(H2,231,302)(H,262,311)(H,263,301)(H,264,303)(H,265,312)(H,266,314)(H,267,313)(H,268,315)(H,269,304)(H,270,318)(H,271,316)(H,272,317)(H,273,319)(H,274,320)(H,275,305)(H,276,309)(H,277,306)(H,278,307)(H,279,310)(H,280,308)(H4,232,233,252)(H4,234,235,253)(H4,236,237,254)(H4,238,239,255)(H4,240,241,256)(H4,242,243,257)(H4,244,245,258)(H4,246,247,259)(H4,248,249,260)(H4,250,251,261);(H,6,7)/t135-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169
InChi Key
FMHIVTRMJLIPAB-VFBKVAFQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Proline-arginine-rich 39 peptide (PR 39 peptide) is an antibacterial peptide.1 It is produced from antibacterial protein PR 39 by extracellular proteases and is primarily expressed by bone marrow-derived immune cells. PR 39 peptide is active against E. coli, S. typhimurium, A. calcoaceticus, B. megaterium, and S. pyogenes (LC50s = 0.3, 1, 3, 0.3, and 2 µM, respectively).2 It inhibits the human 20S proteasome (Ki = 25 nM).3 PR 39 peptide (1 µM) induces calcium-dependent chemotaxis in isolated porcine neutrophils.4 It increases nuclear translocation of hypoxia-inducible factor-1α (HIF-1α) in normoxic- and hypoxic human umbilical vein endothelial cells (HUVECs) when used at a concentration of 5 µM.5 PR 39 induces coronary angiogenesis in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gudmundsson, G.H., Magnusson, K.P., Chowdhary, B.P., et al. Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: Comparative mapping of the locus for the human peptide antibiotic FALL-39. Proc. Natl. Acad. Sci. USA 92(15), 7085-7089 (1995).

    2. Agerberth, B., Lee, J.Y., Bergman, T., et al. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. Eur. J. Biochem. 202(3), 849-854 (1991).

    3. Gaczynska, M., Osmulski, P.A., Gao, Y., et al. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42(29), 8663-8670 (2003).

    4. Huang, H.J., Ross, C.R., and Blecha, F. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. J. Leukoc. Biol. 61(5), 624-629 (1997).

    5. Li, J., Post, M., Volk, R., et al. PR39, a peptide regulator of angiogenesis. Nat. Med. 6(1), 49-55 (2000).