An agonist of NPY receptor Y5
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic Polypeptide (human) (acetate)

Item No. 36718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-prolyl-L-seryl-L-glutaminyl-L-prolyl-L-threonyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-alanyl-2-methylalanyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide, acetate
Molecular Formula
C183H281N57O54S2 • XC2H4O2
Formula Weight
4207.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2 (X = 2-Aminoisobutyric acid)
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
CC(O)=O.OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC(C(C)(C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CO)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]5N(C([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]6N(C([C@H](CC7=CC=C(O)C=C7)NC([C@H]([C@H](O)C)NC([C@H]8N(C([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H]9N(C(CN)=O)CCC9)=O)=O)=O)CCC8)=O)=O)=O)CCC6)=O)=O)=O)=O)=O)=O)CCC5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C183H281N57O54S2.C2H4O2/c1-15-89(4)141(172(289)228-123(82-136(189)254)163(280)219-115(63-74-296-14)150(267)210-93(8)148(265)236-183(11,12)177(294)232-110(29-20-68-205-182(199)200)155(272)216-111(54-58-132(185)250)156(273)214-108(27-18-66-203-180(195)196)152(269)222-117(144(190)261)76-96-34-44-101(245)45-35-96)233-165(282)121(79-99-40-50-104(248)51-41-99)225-154(271)109(28-19-67-204-181(197)198)213-151(268)107(26-17-65-202-179(193)194)215-160(277)118(75-88(2)3)223-146(263)91(6)209-166(283)126(86-241)230-162(279)120(78-98-38-48-103(247)49-39-98)226-161(278)119(77-97-36-46-102(246)47-37-97)224-153(270)106(25-16-64-201-178(191)192)212-145(262)90(5)207-149(266)114(62-73-295-13)218-157(274)112(55-59-133(186)251)217-158(275)113(57-61-139(257)258)220-170(287)130-32-24-72-240(130)176(293)143(95(10)244)235-147(264)92(7)208-159(276)122(81-135(188)253)227-164(281)124(83-140(259)260)211-137(255)85-206-168(285)128-30-22-70-238(128)175(292)125(80-100-42-52-105(249)53-43-100)229-173(290)142(94(9)243)234-171(288)131-33-23-71-239(131)174(291)116(56-60-134(187)252)221-167(284)127(87-242)231-169(286)129-31-21-69-237(129)138(256)84-184;1-2(3)4/h34-53,88-95,106-131,141-143,241-249H,15-33,54-87,184H2,1-14H3,(H2,185,250)(H2,186,251)(H2,187,252)(H2,188,253)(H2,189,254)(H2,190,261)(H,206,285)(H,207,266)(H,208,276)(H,209,283)(H,210,267)(H,211,255)(H,212,262)(H,213,268)(H,214,273)(H,215,277)(H,216,272)(H,217,275)(H,218,274)(H,219,280)(H,220,287)(H,221,284)(H,222,269)(H,223,263)(H,224,270)(H,225,271)(H,226,278)(H,227,281)(H,228,289)(H,229,290)(H,230,279)(H,231,286)(H,232,294)(H,233,282)(H,234,288)(H,235,264)(H,236,265)(H,257,258)(H,259,260)(H4,191,192,201)(H4,193,194,202)(H4,195,196,203)(H4,197,198,204)(H4,199,200,205);1H3,(H,3,4)/t89-,90-,91-,92-,93-,94+,95+,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-;/m0./s1
InChi Key
UEGCMOXRPJTUJG-SJNXXKRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide is an agonist of the neuropeptide Y (NPY) receptor Y5.1 It inhibits cAMP production induced by forskolin (Item No. 11018) in HEK293 cells expressing the human Y5 receptor (EC50 = 17 nM). [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide selectively binds to Y5 (IC50 = 0.24 nM in HEK293 cells expressing the human receptor) over Y1, Y2, and Y4 (IC50s = 530, >500, and 51 nM, respectively, in BHK-21 cells expressing the human receptors). In vitro, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide increases VEGF levels, as well as endothelial branch length and the number of branch points, in 4T1 murine mammary carcinoma cells in a concentration-dependent manner.2 It induces relaxation of vasopressin-precontracted rat mesenteric arteries when used at a concentration of 1 µM.3 Intracranial administration of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide (0.2 and 2 nmol/animal) increases food intake in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cabrele, C., Langer, M., Bader, R., et al. The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. The Journal of Biological Chemisty 275(46), 36043-36048 (2000).

    2. Medeiros, P.J., and Jackson, D.N. Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. Peptides 48, 106-113 (2013).

    3. Gradin, K.A., Li, J.-Y., Zhu, H., et al. Blunted pancreatic polypeptide-induced vasodilatation in mesenteric resistance vessels from spontaneously hypertensive rats. Eur. J. Pharmacol. 601(1-3), 118-123 (2008).