A neuropeptide
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BAM-22P (human, mouse, rat, bovine) (trifluoroacetate salt)

Item No. 36723

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-α-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycine, trifluoroacetate salt
Synonyms
  • Bovine Adrenal Medullary Docosapeptide
  • YGGFMRRVGRPEWWMDYQKRYG
Molecular Formula
C130H184N38O31S2 • XCF3COOH
Formula Weight
2839.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
O=C(NCC(NCC(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CC=C(O)C=C7)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)[C@H](CC9=CC=C(O)C=C9)N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C130H184N38O31S2.C2HF3O2/c1-70(2)108(167-118(191)88(28-16-52-144-129(138)139)157-112(185)86(26-14-50-142-127(134)135)156-116(189)91(47-55-200-3)159-119(192)95(58-71-19-6-5-7-20-71)153-103(174)67-148-102(173)66-149-109(182)82(132)57-72-31-37-77(169)38-32-72)125(198)150-68-104(175)152-93(29-17-53-145-130(140)141)126(199)168-54-18-30-100(168)124(197)161-90(44-46-105(176)177)115(188)164-98(62-76-65-147-84-24-11-9-22-81(76)84)122(195)165-97(61-75-64-146-83-23-10-8-21-80(75)83)121(194)160-92(48-56-201-4)117(190)166-99(63-106(178)179)123(196)163-96(60-74-35-41-79(171)42-36-74)120(193)158-89(43-45-101(133)172)114(187)154-85(25-12-13-49-131)111(184)155-87(27-15-51-143-128(136)137)113(186)162-94(110(183)151-69-107(180)181)59-73-33-39-78(170)40-34-73;3-2(4,5)1(6)7/h5-11,19-24,31-42,64-65,70,82,85-100,108,146-147,169-171H,12-18,25-30,43-63,66-69,131-132H2,1-4H3,(H2,133,172)(H,148,173)(H,149,182)(H,150,198)(H,151,183)(H,152,175)(H,153,174)(H,154,187)(H,155,184)(H,156,189)(H,157,185)(H,158,193)(H,159,192)(H,160,194)(H,161,197)(H,162,186)(H,163,196)(H,164,188)(H,165,195)(H,166,190)(H,167,191)(H,176,177)(H,178,179)(H,180,181)(H4,134,135,142)(H4,136,137,143)(H4,138,139,144)(H4,140,141,145);(H,6,7)/t82-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,108-;/m0./s1
InChi Key
YMMDOCCTXRAIDR-COVUNSQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    BAM-22P is an endogenous neuropeptide derived from proenkephalin A.1 It is expressed primarily in the adrenal medulla and at lower concentrations throughout the brain. BAM-22P binds µ-, κ-, and δ-opioid receptors (Kis = 0.9, 2.9, and 7.2 nM, respectively).2 Intracerebroventricular administration of BAM-22P induces analgesia in a tail-flick assay in mice (ED50 = 6.4 nM).1 It decreases the frequency of tail flicking, as well as paw lifting and licking in a rat model of formalin-induced nocifensive behavior when administered intrathecally at a dose of 5 nM/animal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Höllt, V., Haarmann, I., Grimm, C., et al. Pro-enkephalin intermediates in bovine brain and adrenal medulla: Characterization of immunoreactive peptides related to BAM-22P and peptide F. Life Sci. 31(16-17), 1883-1886 (1982).

    2. Garzón, J., Sánchez-Blázquez, P., Höllt, V., et al. Endogenous opioid peptides: Comparative evaluation of their receptor affinities in the mouse brain. Life Sci. 33(Suppl 1), 291-294 (1983).

    3. Hong, Y., Dai, P., Jiang, J., et al. Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain—potential function of a novel receptor. Br. J. Pharmacol. 141(3), 423-430 (2004).