A peptide inducer of experimental autoimmune uveoretinitis
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IRBP (1-20) (human, rat) (trifluoroacetate salt)

Item No. 36727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-L-aspartic acid, trifluoroacetate salt
Synonyms
  • Interphotoreceptor Retinoid-Binding Protein (1-20)
  • IRBP1-20
Molecular Formula
C101H164N24O28S • XCF3COOH
Formula Weight
2194.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GPTHLFQPSLVLDMAKVLLD-OH
Solubility(Learn about Variance in Solubility)
10% ACN/H2O: Soluble
SMILES
OC(C(F)(F)F)=O.O=C(N1CCC[C@H]1C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC2=CNC=N2)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N3CCC[C@H]3C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)=O)=O)CN[H]
InChi Code
InChI=1S/C101H164N24O28S.C2HF3O2/c1-50(2)37-64(112-91(142)70(43-60-47-105-49-106-60)118-99(150)82(58(16)127)123-96(147)74-28-23-34-124(74)77(129)46-103)86(137)114-69(42-59-25-19-18-20-26-59)90(141)110-63(30-31-76(104)128)100(151)125-35-24-29-75(125)95(146)120-73(48-126)94(145)113-68(41-54(9)10)93(144)122-81(56(13)14)98(149)117-67(40-53(7)8)88(139)115-71(44-78(130)131)92(143)109-62(32-36-154-17)84(135)107-57(15)83(134)108-61(27-21-22-33-102)85(136)121-80(55(11)12)97(148)116-66(39-52(5)6)87(138)111-65(38-51(3)4)89(140)119-72(101(152)153)45-79(132)133;3-2(4,5)1(6)7/h18-20,25-26,47,49-58,61-75,80-82,126-127H,21-24,27-46,48,102-103H2,1-17H3,(H2,104,128)(H,105,106)(H,107,135)(H,108,134)(H,109,143)(H,110,141)(H,111,138)(H,112,142)(H,113,145)(H,114,137)(H,115,139)(H,116,148)(H,117,149)(H,118,150)(H,119,140)(H,120,146)(H,121,136)(H,122,144)(H,123,147)(H,130,131)(H,132,133)(H,152,153);(H,6,7)/t57-,58+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,80-,81-,82-;/m0./s1
InChi Key
JDYFAJISXKDZRH-SELZNHQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $198

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    10 mg

    $307

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    25 mg

    $657

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    Product Description

    Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20) is a dodecapeptide fragment of IRBP, also known as retinoid-binding protein 3, which is involved in pigment regeneration by transporting retinol and retinal from photoreceptor cells to the retinal pigment epithelium.1,2 IRBP1-20 has been used to induce autoimmune uveoretinitis in C57BL/6 mice, which bear the H-2b haplotype.2 IRBP1-20 (3 µM) increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes. Immunization and rechallenge with IRBP1-20 increases ear swelling, ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in IFN-γ-deficient mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zeng, S., T., Z., Madigan, M.C., et al. Interphotoreceptor retinoid-binding protein (IRBP) in retinal health and disease. Front. Cell. Neurosci. 14, 577935 (2020).

    2. Avichezer, D., Chan, C.-C., Silver, P.B., et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp. Eye Res. 71(2), 111-118 (2000).