A synthetic peptide OX2 agonist
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[Ala11,D-Leu15]-Orexin B (acetate)

Item No. 36728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • [Ala11,D-Leu15]-OXB
Molecular Formula
C120H206N44O35S • XC2H4O2
Formula Weight
2857.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
RSGPPGLQGRAQRLXQASGNHAAGILTM-NH2 (X = D-Leucine)
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/mlWater: Soluble
SMILES
CC(O)=O.O=C([C@H](CCCNC(N)=N)N[H])N[C@@H](CO)C(NCC(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@H](C(N[C@H](C(NCC(N[C@@](C(N[C@H](C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CCSC)C(N)=O)=O)=O)CC(C)C)=O)([H])[C@H](CC)C)=O)=O)C)=O)C)=O)=O)=O)=O)=O)C)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C120H206N44O35S.C2H4O2/c1-17-60(10)93(115(197)158-77(44-59(8)9)113(195)162-94(65(15)167)116(198)150-68(95(126)177)34-40-200-16)161-91(175)51-137-96(178)61(11)143-97(179)62(12)146-108(190)78(45-66-47-133-55-142-66)157-112(194)79(46-87(125)171)149-89(173)49-139-102(184)80(53-165)159-99(181)64(14)145-105(187)72(29-32-85(123)169)154-110(192)75(42-57(4)5)156-111(193)76(43-58(6)7)155-106(188)70(25-20-37-136-120(131)132)152-107(189)73(30-33-86(124)170)151-98(180)63(13)144-104(186)69(24-19-36-135-119(129)130)147-88(172)48-138-101(183)71(28-31-84(122)168)153-109(191)74(41-56(2)3)148-90(174)50-140-114(196)82-26-21-39-164(82)117(199)83-27-22-38-163(83)92(176)52-141-103(185)81(54-166)160-100(182)67(121)23-18-35-134-118(127)128;1-2(3)4/h47,55-65,67-83,93-94,165-167H,17-46,48-54,121H2,1-16H3,(H2,122,168)(H2,123,169)(H2,124,170)(H2,125,171)(H2,126,177)(H,133,142)(H,137,178)(H,138,183)(H,139,184)(H,140,196)(H,141,185)(H,143,179)(H,144,186)(H,145,187)(H,146,190)(H,147,172)(H,148,174)(H,149,173)(H,150,198)(H,151,180)(H,152,189)(H,153,191)(H,154,192)(H,155,188)(H,156,193)(H,157,194)(H,158,197)(H,159,181)(H,160,182)(H,161,175)(H,162,195)(H4,127,128,134)(H4,129,130,135)(H4,131,132,136);1H3,(H,3,4)/t60-,61-,62-,63-,64-,65+,67-,68-,69-,70-,71-,72-,73-,74-,75+,76-,77-,78-,79-,80-,81-,82-,83-,93-,94-;/m0./s1
InChi Key
YZIAJNXATJJVEI-TUXBMQPLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $219

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    1 mg

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    5 mg

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    Product Description

    [Ala11,D-Leu15]-Orexin B is a synthetic peptide agonist of the orexin 2 (OX2) receptor.1 It selectively induces calcium mobilization in CHO-K1 cells expressing OX2 over CHO-K1 cells expressing OX1 (EC50s = 0.13 and 52 nM, respectively, for the human receptors). [Ala11,D-Leu15]-Orexin B inhibits forskolin-, PACAP (1-27)-, or VIP-induced cAMP formation in primary rat neuronal cells (IC50s = 42, 32.3, and 22.9 nM, respectively).2 It increases mean arterial pressure (MAP), heart rate, and phrenic nerve activity in rats when intracranially administered at a dose of 0.75 pmol/animal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asahi, S., Egashire, S.-I., Matsuda, M., et al. Development of an orexin-2 receptor selective agonist, [Ala11, D-Leu15]orexin-B. Bioorg. Med. Chem. Lett. 13(1), 111-113 (2003).

    2. Urbanska, A., Sokolowska, P., Woldan-Tambor, A., et al. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. J. Mol. Neurosci. 46(1), 10-17 (2012).

    3. Shahid, I.Z., Rahman, A.A., and Pilowsky, P.M. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex. Brit. J. Pharmacol. 165(7), 2292-2303 (2011).