A cell-permeable stearated peptide
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st-Ht31 (ammonium salt)

Item No. 36745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-oxooctadecyl)-L-α-aspartyl-L-leucyl-L-isoleucyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-alanyl-L-seryl-L-arginyl-L-isoleucyl-L-valyl-L-α-aspartyl-L-alanyl-L-valyl-L-isoleucyl-L-α-glutamyl-L-glutaminyl-L-valyl-L-lysyl-L-alanyl-L-alanylglycyl-L-alanyl-L-tyrosine, ammonium salt
Synonyms
  • sHt31
Molecular Formula
C129H217N29O39 • XNH4
Formula Weight
2798.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
stearoyl-DLIEEAASRIVDAVIEQVKAAGAY-OH
Solubility(Learn about Variance in Solubility)
30% ACN/H2O: Soluble
SMILES
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](C)NC(CNC([C@H](C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC(CCCCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.[NH4+]
InChi Code
InChI=1S/C129H217N29O39.H3N/c1-22-26-27-28-29-30-31-32-33-34-35-36-37-38-39-45-93(162)142-88(62-98(170)171)119(187)149-87(60-66(5)6)120(188)157-103(70(13)23-2)125(193)147-86(53-57-97(168)169)115(183)145-84(51-55-95(164)165)113(181)140-76(19)108(176)138-77(20)110(178)152-91(65-159)121(189)143-82(44-42-59-134-129(132)133)116(184)156-105(72(15)25-4)127(195)155-101(68(9)10)123(191)150-89(63-99(172)173)118(186)141-78(21)111(179)153-102(69(11)12)124(192)158-104(71(14)24-3)126(194)148-85(52-56-96(166)167)114(182)144-83(50-54-92(131)161)117(185)154-100(67(7)8)122(190)146-81(43-40-41-58-130)112(180)139-75(18)107(175)137-73(16)106(174)135-64-94(163)136-74(17)109(177)151-90(128(196)197)61-79-46-48-80(160)49-47-79;/h46-49,66-78,81-91,100-105,159-160H,22-45,50-65,130H2,1-21H3,(H2,131,161)(H,135,174)(H,136,163)(H,137,175)(H,138,176)(H,139,180)(H,140,181)(H,141,186)(H,142,162)(H,143,189)(H,144,182)(H,145,183)(H,146,190)(H,147,193)(H,148,194)(H,149,187)(H,150,191)(H,151,177)(H,152,178)(H,153,179)(H,154,185)(H,155,195)(H,156,184)(H,157,188)(H,158,192)(H,164,165)(H,166,167)(H,168,169)(H,170,171)(H,172,173)(H,196,197)(H4,132,133,134);1H3/p+1/t70-,71-,72-,73-,74-,75-,76-,77-,78-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-,101-,102-,103-,104-,105-;/m0./s1
InChi Key
UDOICUPVNXODHQ-WJMNIFNHSA-O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    st-Ht31 is a cell-permeable stearated peptide derived from the amphipathic helix domain from A-kinase anchoring proteins (AKAPs), which binds protein kinase A (PKA).1,2 It decreases PKA membrane anchoring but not activity in a reporter assay using BHK-21 fibroblasts when used at a concentration of 50 µM.2 st-Ht31 (1 and 3 µM) reduces capacitance and hyperactivation, as well as prevents in vitro fertilization, in mouse sperm.1 It increases cholesterol export from BHK-21 cells and RAW 264.7 macrophages expressing ATP-binding cassette transporter 1 (ABCA1) when used at a concentration of 50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stival, C., Ritagliati, C., Xu, X., et al. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. The Journal of Biological Chemisty 293(23), 9435-9447 (2018).

    2. Ma, L., Dong, F., Denis, M., et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. The Journal of Biological Chemisty 286(5), 3370-3378 (2011).