A peptide agonist of CMKLR1 and CMKLR2
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Chemerin-9 (human) (acetate)

Item No. 36760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-phenylalanyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-serine, acetate
Synonyms
  • Chemerin (149-157)
  • YFPGQFAFS
Molecular Formula
C54H66N10O13 • XC2H4O2
Formula Weight
1063.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 12 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.3 mg/ml
SMILES
O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](CO)C(O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@@H](NC([C@@H](N)CC(C=C4)=CC=C4O)=O)CC5=CC=CC=C5.CC(O)=O
InChi Code
InChI=1S/C54H66N10O13.C2H4O2/c1-32(47(69)60-41(28-34-14-7-3-8-15-34)51(73)63-43(31-65)54(76)77)58-50(72)40(27-33-12-5-2-6-13-33)61-49(71)39(23-24-45(56)67)59-46(68)30-57-52(74)44-18-11-25-64(44)53(75)42(29-35-16-9-4-10-17-35)62-48(70)38(55)26-36-19-21-37(66)22-20-36;1-2(3)4/h2-10,12-17,19-22,32,38-44,65-66H,11,18,23-31,55H2,1H3,(H2,56,67)(H,57,74)(H,58,72)(H,59,68)(H,60,69)(H,61,71)(H,62,70)(H,63,73)(H,76,77);1H3,(H,3,4)/t32-,38-,39-,40-,41-,42-,43-,44-;/m0./s1
InChi Key
HJEXDFJBTIHVPO-CPIFIIIUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $62

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    1 mg

    $117

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    5 mg

    $304

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    10 mg

    $546

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    Product Description

    Chemerin-9 is a peptide agonist of chemokine-like receptor 1 (CMKLR1) and CMKLR2, also known as chemerin receptor 1 (chemerin1) and chemerin2, respectively.1 It is composed of nine C-terminal amino acids of the endogenous human protein chemerin, a chemotactic protein and adipokine involved in the early immune response and energy homeostasis.2 Chemerin-9 binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively, in a radioligand binding assay) and induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Gα15 when used at a concentration of 1 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wittamer, V., Grégoire, F., Robberecht, P., et al. The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. The Journal of Biological Chemisty 279(11), 9956-9962 (2004).

    2. Fischer, T.F., and Beck-Sickinger, A.G. Chemerin - exploring a versatile adipokine. Biol. Chem. 403(7), 625-642 (2022).

    3. Barnea, G., Strapps, W., Herrada, G., et al. The genetic design of signaling cascades to record receptor activation. Proc. Natl. Acad. Sci. USA 105(1), 64-69 (2008).