A peptide TRPV6 antagonist
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SOR-C13 (trifluoroacetate salt)

Item No. 36764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-histidyl-L-prolyl-L-seryl-L-lysyl-L-valyl-L-α-aspartyl-L-leucyl-L-prolyl-L-arginine, trifluoroacetate salt
Molecular Formula
C72H116N20O19 • XCF3COOH
Formula Weight
1565.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
NCCCC[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CCCCN)=O)CO)=O)CCC3)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C72H116N20O19.C2HF3O2/c1-39(2)31-48(84-63(102)49(33-42-17-8-7-9-18-42)85-60(99)46(24-25-56(94)95)81-59(98)44(75)19-10-12-26-73)62(101)88-52(34-43-36-78-38-80-43)70(109)92-30-16-23-55(92)67(106)89-53(37-93)65(104)82-45(20-11-13-27-74)61(100)90-58(41(5)6)68(107)86-50(35-57(96)97)64(103)87-51(32-40(3)4)69(108)91-29-15-22-54(91)66(105)83-47(71(110)111)21-14-28-79-72(76)77;3-2(4,5)1(6)7/h7-9,17-18,36,38-41,44-55,58,93H,10-16,19-35,37,73-75H2,1-6H3,(H,78,80)(H,81,98)(H,82,104)(H,83,105)(H,84,102)(H,85,99)(H,86,107)(H,87,103)(H,88,101)(H,89,106)(H,90,100)(H,94,95)(H,96,97)(H,110,111)(H4,76,77,79);(H,6,7)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,58-;/m0./s1
InChi Key
XDOCHJQBBDGBNT-XIZUHFEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    SOR-C13 is a peptide antagonist of transient receptor potential vanilloid 6 (TRPV6).1 It inhibits calcium flux in HEK293 cells expressing human TRPV6 (EC50 = 14 nM). SOR-C13 (400, 600, and 800 mg/kg) reduces tumor volume in an SKOV3 ovarian cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, H., Wang, Y., MacCormack, T.J., et al. Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model. J. Cancer 9(17), 3196-3207 (2018).