A neuropeptide fragment of ProSAAS and a GPR171 agonist
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BigLEN (mouse) (acetate)

Item No. 36766

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-seryl-L-prolyl-L-glutaminyl-L-alanyl-L-prolyl-L-alanyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-prolyl-L-proline, acetate
Molecular Formula
C78H130N24O22 • XC2H4O2
Formula Weight
1756.0
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
LENPSPQAPARRLLPP-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N1[C@H](C(N2[C@H](C(O)=O)CCC2)=O)CCC1)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@@H](NC([C@@H]4CCCN4C([C@@H](NC([C@H]5N(C([C@H](CC(N)=O)NC([C@@H](NC([C@@H](N)CC(C)C)=O)CCC(O)=O)=O)=O)CCC5)=O)CO)=O)=O)CCC(N)=O)=O)C)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C.OC(C)=O
InChi Code
InChI=1S/C78H130N24O22.C2H4O2/c1-39(2)34-44(79)62(109)91-48(24-26-60(106)107)66(113)96-51(37-59(81)105)73(120)99-30-12-20-55(99)70(117)97-52(38-103)74(121)100-31-13-19-54(100)69(116)93-47(23-25-58(80)104)63(110)89-43(8)71(118)98-29-11-18-53(98)68(115)88-42(7)61(108)90-45(16-9-27-86-77(82)83)64(111)92-46(17-10-28-87-78(84)85)65(112)94-49(35-40(3)4)67(114)95-50(36-41(5)6)72(119)101-32-14-21-56(101)75(122)102-33-15-22-57(102)76(123)124;1-2(3)4/h39-57,103H,9-38,79H2,1-8H3,(H2,80,104)(H2,81,105)(H,88,115)(H,89,110)(H,90,108)(H,91,109)(H,92,111)(H,93,116)(H,94,112)(H,95,114)(H,96,113)(H,97,117)(H,106,107)(H,123,124)(H4,82,83,86)(H4,84,85,87);1H3,(H,3,4)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-;/m0./s1
InChi Key
XPYPWOMFQXHFEX-SFYVOUIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $252

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    5 mg

    $597

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    Product Description

    BigLEN is a neuropeptide and fragment of the pro-protein ProSAAS, involved in food intake, and an agonist of the orphan G protein-coupled receptor 171 (GPR171).1 It selectively increases intracellular calcium levels in CHO cells expressing GPR171 over those expressing GPR19, GPR108, or GPR165 at 1 µM. BigLEN (10 µM) increases neurite outgrowth in mouse Neuro2a neuroblastoma cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gomes, I., Aryal, D.K., Wardman, J.H., et al. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc. Natl. Acad. Sci. USA 110(40), 16211-16216 (2013).