An HCV NS5A inhibitor
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Samatasvir

Item No. 36776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-2-[(2S)-2-[5-[4-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]thieno[3,2-b]thien-3-yl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-carbamic acid, methyl ester
CAS Number
1312547-19-5
Synonyms
  • IDX719
  • IDX18719
Molecular Formula
C47H48N8O6S2
Formula Weight
885.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 1 mg/ml
SMILES
O=C([C@H](C(C)C)NC(OC)=O)N1CCC[C@@]1([H])C(N2)=NC(C2=C3)=CC=C3C4=CSC5=C4SC=C5C6=CC=C(C7=CN=C([C@]8([H])CCCN8C([C@@H](C9=CC=CC=C9)NC(OC)=O)=O)N7)C=C6
InChi Code
InChI=1S/C47H48N8O6S2/c1-26(2)38(52-46(58)60-3)44(56)55-21-9-13-37(55)43-49-33-19-18-30(22-34(33)50-43)32-25-63-40-31(24-62-41(32)40)27-14-16-28(17-15-27)35-23-48-42(51-35)36-12-8-20-54(36)45(57)39(53-47(59)61-4)29-10-6-5-7-11-29/h5-7,10-11,14-19,22-26,36-39H,8-9,12-13,20-21H2,1-4H3,(H,48,51)(H,49,50)(H,52,58)(H,53,59)/t36-,37-,38-,39+/m0/s1
InChi Key
ATOLIHZIXHZSBA-BTSKBWHGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Samatasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A).1 It inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1a, -1b, -2a, -3a, -4a, and -5a (EC50s = 2-24 pM). Samatasvir acts additively with the nucleotide prodrug IDX184, NS5B inhibitor TMC647055, or NS3/4A protease inhibitor simeprevir (Item No. 22144) to inhibit viral replication in genotype 1b HCV replicon cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bilello, J.P., Lallos, L.B., McCarville, J.F., et al. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus. Antimicrob. Agents Chemother. 58(8), 4431-4442 (2014).