CFM 4

CFM 4 is an inhibitor of the protein-protein interaction between anaphase-promoting complex subunit 2 (APC2) and cell cycle and apoptosis regulatory protein 1 (CARP-1).¹ It inhibits the binding of APC2 to CARP-1 (IC₅₀ = 0.75 µM). CFM 4 reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner. It induces cell cycle arrest at the G₀ phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells when used at a concentration of 20 µM. Nanostructure lipid carrier-encapsulated CFM 4 (40 mg/kg every other day) reduces tumor growth in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.²

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1. Puliyappadamba, V.T., Wu, W., Bevis, D., et al. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. The Journal of Biological Chemisty 286(44), 38000-38017 (2011).

2. Muthu, M., Somagoni, J., Cheriyan, V.T., et al. Identification and testing of novel CARP-1 functional mimetic compounds as inhibitors of non-small cell lung and triple negative breast cancers. J. Biomed. Nanotechnol. 11(9), 1608-1627 (2015).