A mitochondrial complex I inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DX3-213B

Item No. 36783

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-(4,4-difluoropiperidin-1-yl)(1-((4-(isopropylsulfonyl)phenyl)sulfonyl)piperidin-3-yl)methanone
CAS Number
2749555-66-4
Molecular Formula
C20H28F2N2O5S2
Formula Weight
478.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
SMILES
O=S(N1C[C@@H](CCC1)C(N2CCC(F)(CC2)F)=O)(C3=CC=C(C=C3)S(C(C)C)(=O)=O)=O
InChi Code
InChI=1S/C20H28F2N2O5S2/c1-15(2)30(26,27)17-5-7-18(8-6-17)31(28,29)24-11-3-4-16(14-24)19(25)23-12-9-20(21,22)10-13-23/h5-8,15-16H,3-4,9-14H2,1-2H3/t16-/m1/s1
InChi Key
HLSJMSNPBRGRGL-MRXNPFEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $82

    Add

    5 mg

    $363

    Add

    10 mg

    $603

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    DX3-213B is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 3.6 nM).1 It inhibits the proliferation of MiaPaCa-2 cells cultured in galactose- but not glucose-containing media (IC50s = 9.1 and >3,000 nM, respectively). DX3-213B (10 mg/kg) reduces tumor volume in a Panc02 murine pancreatic ductal adenocarcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, D., Xu, Y., Kyani, A., et al. Multiparameter optimization of oxidative phosphorylation inhibitors for the treatment of pancreatic cancer. J. Med. Chem. 65(4), 3404-3419 (2022).