An AdPLA2 inhibitor
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LEI-110

Item No. 36789

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-benzenepentanamide
CAS Number
2313525-90-3
Molecular Formula
C25H23F3N2O3
Formula Weight
456.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
SMILES
O=C(C(CCCC1=CC=CC=C1)=O)NCCC2=CC=C(C=C2)OC3=CC=C(C(F)(F)F)C=N3
InChi Code
InChI=1S/C25H23F3N2O3/c26-25(27,28)20-11-14-23(30-17-20)33-21-12-9-19(10-13-21)15-16-29-24(32)22(31)8-4-7-18-5-2-1-3-6-18/h1-3,5-6,9-14,17H,4,7-8,15-16H2,(H,29,32)
InChi Key
DZHZISUSQMPBJQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

    $363

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    10 mg

    $684

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    Product Description

    LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, J., Mock, E.D., Martella, A., et al. Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVI. ACS Chem. Biol. 14(2), 164-169 (2019).