A plant metabolite with diverse biological activities
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Asaraldehyde

Item No. 36798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,5-trimethoxy-benzaldehyde
CAS Number
4460-86-0
Synonyms
  • Asaronaldehyde
  • Asarylaldehyde
  • NSC 89299
  • 2,4,5-Trimethoxybenzaldehyde
Molecular Formula
C10H12O4
Formula Weight
196.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
λmax
236, 275, 342 nm
SMILES
O=CC1=CC(OC)=C(C=C1OC)OC
InChi Code
InChI=1S/C10H12O4/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-6H,1-3H3
InChi Key
IAJBQAYHSQIQRE-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    25 g

    $51

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    50 g

    $82

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    100 g

    $142

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    250 g

    $329

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    Product Description

    Asaraldehyde is a plant metabolite that has been found in D. carota and has diverse biological activities.1,2,3,4 It selectively inhibits COX-2 over COX-1 when used at a concentration of 100 µg/ml and inhibits aggregation of washed isolated rabbit platelet-rich plasma induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or collagen (IC50s = 53.7 and 27.6 µM, respectively).1,2 Asaraldehyde (1 mg/disc) is active against C. perfringens and C. difficile.2 It decreases triglyceride, perilipin 1, and leptin levels and increases glycerol and hormone-sensitive lipase (HSL) levels in differentiated 3T3-L1 mouse adipocytes, as well as enhances osteogenesis induced by osteogenic differentiation medium in primary human periodontal ligament stem cells when used at a concentration of 100 µg/ml.3,4 Asaraldehyde has been used as a building block in the synthesis of various chalcones and flavonoids with anticancer and antioxidant activities.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Momin, R.A., De Witt, D.L., and Nair, M.G. Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. seeds. Phytother. Res. 17(8), 976-979 (2003).

    2. Kim, H.-G., Jeon, J.-H., Kim, M.-K., et al. Pharmacological effects of asaronaldehyde isolated from Acorus gramineus rhizome. Food Sci. Biotechnol. 14(5), 685-688 (2005).

    3. Wu, M.-R., Hou, M.-H., Lin, Y.-L., et al. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J. Agric. Food Chem. 60(29), 7262-7269 (2012).

    4. Hwang, J.W., Park, W.-J., and Han, Y. Asarylaldehyde enhances osteogenic differentiation of human periodontal ligament stem cells through the ERK/p38 MAPK signaling pathway. Biochem. Biophys. Res. Commun. 545, 27-32 (2021).

    5. Shenvi, S., Kumar, K., Hatti, K.S., et al. Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: Structure-activity relationship. Eur. J. Med. Chem. 62, 435-442 (2013).