An IKr inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AM92016 (hydrochloride)

Item No. 36803

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, monohydrochloride
CAS Number
133229-11-5
Molecular Formula
C19H24Cl2N2O4S • HCl
Formula Weight
483.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
SMILES
O=S(NC1=CC=C(C=C1)OCC(CN(CCC2=CC=C(C(Cl)=C2)Cl)C)O)(C)=O.Cl
InChi Code
InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26;/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3;1H
InChi Key
TXOARFPCQOBODS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $124

    Add

    10 mg

    $220

    Add

    25 mg

    $307

    Add

    50 mg

    $552

    Add
    Product Description

    AM92016 is an inhibitor of delayed-rectifier potassium current (IKr; IC50 = 40 nM in isolated rabbit sinoatrial node cells).1 It is selective for IKr over L-type voltage-gated calcium (Cav) current and hyperpolarization-activated inward current (If) at 1 µM. AM92016 (50 nM) decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells. It decreases the QT interval and increases heart rate in anesthetized guinea pigs when administered at a dose of 1 mg/kg.2 AM92016 (1 mg/kg) decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lei, M., and Brown, H.F. Inhibition by Compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit isolated sino-atrial node cells. Naunyn Schmiedebergs Arch Pharmacol. 357(3), 260-267 (1998).

    2. Hagerty, M.J., Wainwright, C.L., and Kane, K.A. The in-vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J. Pharm. Pharmacol. 48(4), 417-421 (1996).