An H+/K+-ATPase inhibitor
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AZD 0865

Item No. 36805

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
CAS Number
248919-64-4
Synonyms
  • Linaprazan
Molecular Formula
C21H26N4O2
Formula Weight
366.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
262 nm
SMILES
O=C(C1=CN2C(C)=C(C)N=C2C(NCC3=C(C)C=CC=C3C)=C1)NCCO
InChi Code
InChI=1S/C21H26N4O2/c1-13-6-5-7-14(2)18(13)11-23-19-10-17(21(27)22-8-9-26)12-25-16(4)15(3)24-20(19)25/h5-7,10,12,23,26H,8-9,11H2,1-4H3,(H,22,27)
InChi Key
GHVIMBCFLRTFHI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $196

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    10 mg

    $347

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    25 mg

    $758

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    Product Description

    AZD 0865 is a potassium-competitive inhibitor of the gastric H+/K+-ATPase (Ki = 46 nM).1 It inhibits histamine- or dibutyryrl-cAMP-induced acid production in isolated rabbit gastric glands (IC50s = 0.28 and 0.26 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gedda, K., Briving, C., Svensson, K., et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem. Pharmacol. 73(2), 198-205 (2007).