An inhibitor of HIV-1 integrase DNA strand transfer
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HIV-1 Integrase Inhibitor 1

Item No. 36807

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide
CAS Number
729607-74-3
Synonyms
  • BMS-707035
Molecular Formula
C17H19FN4O5S
Formula Weight
410.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble
λmax
253, 302 nm
SMILES
O=C(C(N=C(N1CCCCS1(=O)=O)N2C)=C(O)C2=O)NCC3=CC=C(C=C3)F
InChi Code
InChI=1S/C17H19FN4O5S/c1-21-16(25)14(23)13(15(24)19-10-11-4-6-12(18)7-5-11)20-17(21)22-8-2-3-9-28(22,26)27/h4-7,23H,2-3,8-10H2,1H3,(H,19,24)
InChi Key
VNIWZCGZPBJWBI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    HIV-1 integrase inhibitor 1 is an inhibitor of HIV-1 integrase DNA strand transfer (IC50 = 14 nM).1 It is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), when used at a concentration of 10 µM in a fluorescence-based assay.2 HIV-1 integrase inhibitor 1 decreases SARS-CoV-2 replication (EC50 = 0.27 µM) and reduces particle-forming units (PFUs) in infected Huh7.5 cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Langley, D.R., Samanta, H.K., Lin, Z., et al. The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors. Biochemistry 47(51), 13481-13488 (2008).

    2. Narayanan, A., Narwal, M., Majowicz, S.A., et al. Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay. Commun. Biol. 5(1), 169 (2022).