An anticoagulant reversal agent
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Ciraparantag (trifluoroacetate salt)

Item No. 36809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,2′S)-N,N′-(1,4-piperazinediyldi-3,1-propanediyl)bis[2-amino-5-[(aminoiminomethyl)amino]-pentanamide, trifluoroacetate salt
Synonyms
  • PER977
Molecular Formula
C22H48N12O2 • XCF3COOH
Formula Weight
512.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: 10 mg/mlWater: 10 mg/ml
SMILES
N=C(N)NCCC[C@H](N)C(NCCCN1CCN(CC1)CCCNC([C@@H](N)CCCNC(N)=N)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C22H48N12O2.C2HF3O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28;3-2(4,5)1(6)7/h17-18H,1-16,23-24H2,(H,29,35)(H,30,36)(H4,25,26,31)(H4,27,28,32);(H,6,7)/t17-,18-;/m0./s1
InChi Key
AEMJKCYSGBYLRS-APTPAJQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $80

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    25 mg

    $174

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    50 mg

    $304

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    Product Description

    Ciraparantag is an anticoagulant reversal agent.1,2 It selectively binds to unfractionated heparin, enoxaparin, and Factor IXa (Kds = 28, 17, and 35 µM, respectively) over edoxaban (Item No. 24030), rivaroxaban (Item No. 16043), Factor Xa, Factor IX, thrombin (Item No. 13188), antithrombin, and fibrinogen, and only weakly binds to an enoxaparin-antithrombin complex and fondaparinux (Item No. 24033; Kds = 690 and 9,600 µM, respectively), in cell-free assays.1 Ciraparantag (200 µg/ml) prevents decreases in fibrin diameter induced by the Factor Xa inhibitor edoxaban in isolated human whole blood. It reduces edoxaban-, dabigatran-, apixaban-, rivaroxaban-, unfractionated heparin-, or enoxaparin-stimulated increases in tail transection-induced blood loss in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kalathottukaren, M.T., Creagh, A.L., Abbina, S., et al. Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors. Blood Adv. 2(16), 2104-2114 (2018).

    2. Ansell, J., Laulicht, B.E., Bakhru, S.H., et al. Ciraparantag, an anticoagulant reversal drug: Mechanism of action, pharmacokinetics, and reversal of anticoagulants. Blood 137(1), 115-125 (2021).