An inhibitor of SOC and Cav1 channels
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MRS1845

Item No. 36814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propyn-1-yl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester
CAS Number
544478-19-5
Molecular Formula
C21H22N2O6
Formula Weight
398.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
O=C(C(C(C1=CC([N+]([O-])=O)=CC=C1)C(C(OC)=O)=C2C)=C(N2CC#C)C)OCC
InChi Code
InChI=1S/C21H22N2O6/c1-6-11-22-13(3)17(20(24)28-5)19(18(14(22)4)21(25)29-7-2)15-9-8-10-16(12-15)23(26)27/h1,8-10,12,19H,7,11H2,2-5H3
InChi Key
BITHABUTZRAUGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    MRS1845 is an inhibitor of store-operated calcium (SOC) channels (IC50 = 1.7 µM in HL-60 leukemia cells) and the L-type voltage-gated calcium channel Cav1 (IC50 = 2.1 µM in GH4C1 rat pituitary cells).1 It reduces calcium entry induced by the sarcoplasmic/endoplasmic Ca2+-ATPase (SERCA) inhibitor thapsigargin (Item No. 10522) in isolated rat polymorphonuclear leukocytes (PMNs) after administration of a 1.2 mg/kg dose.2 MRS1845 (1.2 mg/kg) decreases shock-induced increases in ITGAM/CD11b levels in PMNs isolated from rats in a model of traumatic hemorrhagic shock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harper, J.L., Camerini-Otero, C.S., Li, A.-H., et al. Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem. Pharmacol. 65(3), 329-338 (2003).

    2. Lee, C., Xu, D.-Z., Feketeova, E., et al. Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury. Shock 30(1), 29-35 (2008).