An inhibitor of JARID1B
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KDM5-C70

Item No. 36817

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-4-pyridinecarboxylic acid, ethyl ester
CAS Number
1596348-32-1
Synonyms
  • KDOAM-21
Molecular Formula
C17H28N4O3
Formula Weight
336.4
Purity
≥95%
Formulation
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleDMSO: SolubleEthanol: Soluble
SMILES
O=C(C1=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C1)OCC
InChi Code
InChI=1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8,11,18H,5-6,9-10,12-13H2,1-4H3
InChi Key
WCILOMUUNVPIKQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $109

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    25 mg

    $191

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    Product Description

    KDM5-C70 is an inhibitor of Jumonji AT rich interactive domain 1B (JARID1B), also known as lysine-specific demethylase 5B (KDM5B; IC50 = 49 nM).1 It is selective for JARID1B over KDM4C (IC50 = 2,400 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tumber, A., Nuzzi, A., Hookway, E.S., et al. Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells. Cell Chem. Biol. 24(3), 371-380 (2017).