An ENPP1 inhibitor
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ENPP1 Inhibitor 43

Item No. 36836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-butanamide
CAS Number
2631703-41-6
Molecular Formula
C16H18N6O3S
Formula Weight
374.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
λmax
216, 242, 310 nm
SMILES
O=C(C(CC)SC1=NC(N)=NC2=C1NC=N2)NC3=CC=C(C(OC)=C3)O
InChi Code
InChI=1S/C16H18N6O3S/c1-3-11(14(24)20-8-4-5-9(23)10(6-8)25-2)26-15-12-13(19-7-18-12)21-16(17)22-15/h4-7,11,23H,3H2,1-2H3,(H,20,24)(H3,17,18,19,21,22)
InChi Key
ZDCMJGUVFRHQEH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $94

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    5 mg

    $418

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    10 mg

    $697

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    Cayman Chemical
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    Product Description

    ENPP1 inhibitor 43 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1; Ki = 41 nM).1 It inhibits tumor growth in an LLC1 murine lung cancer model when administered orally or intravenously at doses of 10 and 100 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gangar, M., Goyal, S., Raykar, D., et al. Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy. Bioorg. Chem. 119, 105549 (2022).