An inhibitor of MMP-13
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BI-4394

Item No. 36855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylic acid, 2-ethyl ester
CAS Number
1222173-37-6
Molecular Formula
C24H22N4O5
Formula Weight
446.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mM
SMILES
O=C(OCC)C1=CC2=C(N1)C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2
InChi Code
InChI=1S/C24H22N4O5/c1-3-33-24(32)20-11-17-10-16(8-9-18(17)26-20)21-12-19(27-28(21)2)22(29)25-13-14-4-6-15(7-5-14)23(30)31/h4-12,26H,3,13H2,1-2H3,(H,25,29)(H,30,31)
InChi Key
MMJPVSDTLGFIQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $101

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    5 mg

    $476

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    10 mg

    $800

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    Product Description

    BI-4394 is an inhibitor of matrix metalloproteinase-13 (MMP-13; IC50 = 0.001 µM for the recombinant human enzyme).1 It is selective for MMP-13 over MMP-1-3, 7-10, -12, and -14 with IC50 values ranging from 8.3 to greater than 22 µM for the recombinant human enzymes. BI-4394 inhibits the degradation of isolated bovine nasal cartilage explants cultured with human MMP-13 (IC50 = 0.031 µM). It decreases disease severity in a mouse model of anti-type II collagen antibody and LPS-induced arthritis when administered at a dose of 100 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Taylor, S.J., Abeywardane, A., Liang, S., et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem. 54(23), 8174-8187 (2011).

    2. Taylor, S.J., Abeywardane, A., Liang, S., et al. Indole inhibitors of MMP-13 for arthritic disorders. ACS Omega 6(29), 18635-18650 (2021).