A neuropeptide and fragment of VGF
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TLQP 21 (trifluoroacetate salt)

Item No. 36864

Product Insert (PDF)
Technical Information
Formal Name
L-threonyl-L-leucyl-L-glutaminyl-L-prolyl-L-prolyl-L-alanyl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-histidyl-L-phenylalanyl-L-histidyl-L-histidyl-L-alanyl-L-leucyl-L-prolyl-L-prolyl-L-alanyl-L-arginine, trifluoroacetate salt
Synonyms
  • Neurosecretory Protein VGF (556-576) (mouse, rat)
  • VGF (non-acronymic) (556-576) (mouse, rat)
Molecular Formula
C107H170N40O26 • XCF3COOH
Formula Weight
2432.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
TLQPPASSRRRHFHHALPPAR-OH
Solubility(Learn about Variance in Solubility)
Water: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@H](C(N[C@@H](CCC(N)=O)C(N1CCC[C@H]1C(N2CCC[C@H]2C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC=N3)C(N[C@H](C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)C)=O)=O)=O)CC(C)C)=O)C)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)[C@@]([C@H](O)C)([H])N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C107H170N40O26.C2HF3O2/c1-54(2)40-69(140-98(167)82(109)59(8)150)90(159)134-67(30-31-81(108)151)99(168)146-38-18-28-79(146)101(170)144-36-16-27-78(144)97(166)130-58(7)85(154)142-75(49-148)95(164)143-76(50-149)94(163)133-65(23-13-33-122-105(112)113)87(156)131-64(22-12-32-121-104(110)111)86(155)132-66(24-14-34-123-106(114)115)88(157)137-72(44-62-47-119-52-126-62)92(161)136-70(42-60-20-10-9-11-21-60)91(160)139-73(45-63-48-120-53-127-63)93(162)138-71(43-61-46-118-51-125-61)89(158)128-56(5)84(153)141-74(41-55(3)4)100(169)147-39-19-29-80(147)102(171)145-37-17-26-77(145)96(165)129-57(6)83(152)135-68(103(172)173)25-15-35-124-107(116)117;3-2(4,5)1(6)7/h9-11,20-21,46-48,51-59,64-80,82,148-150H,12-19,22-45,49-50,109H2,1-8H3,(H2,108,151)(H,118,125)(H,119,126)(H,120,127)(H,128,158)(H,129,165)(H,130,166)(H,131,156)(H,132,155)(H,133,163)(H,134,159)(H,135,152)(H,136,161)(H,137,157)(H,138,162)(H,139,160)(H,140,167)(H,141,153)(H,142,154)(H,143,164)(H,172,173)(H4,110,111,121)(H4,112,113,122)(H4,114,115,123)(H4,116,117,124);(H,6,7)/t56-,57-,58-,59+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,82-;/m0./s1
InChi Key
DYHUGCMDAKBNIR-NEZLXJQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    TLQP 21 is a neuropeptide and fragment of the neurosecretory protein VGF (non-acronymic).1 It is produced by cleavage of pro-VGF by prohormone convertases. TLQP 21 selectively activates the complement C3a receptor (C3aR; EC50 = 83.6 nM in CHO cells expressing the human receptor) over C5a1 and C5a2 at 10 µM and induces phosphorylation of ERK1/2 in primary mouse bone marrow-derived macrophages (BMDMs), which endogenously express C3aR (EC50 = 96.5 nM). It also induces increases in intracellular calcium in primary mouse BMDMs, which can be inhibited by monoclonal antibodies targeting the globular C1q receptor (gC1qR).2 Intraplantar hind paw injection of TLQP 21-activated macrophages induces mechanical hypersensitivity in rats. TLQP 21 (25 µg/animal, i.c.v.) decreases food intake and body weight in hamsters.3 It also increases serum luteinizing hormone (LH) levels in pre-pubertal female rats when administered intraperitoneally but not intracerebroventricularly.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X.X., Lee, J.D., Lee, H.S., et al. TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Front. Immunol. 14:1086673, (2023).

    2. Chen, Y.-C., Pristerá, A., Ayub, M., et al. Identification of a receptor for neuropeptide VGF and its role in neuropathic pain. The Journal of Biological Chemisty 288(48), 34638-34646 (2013).

    3. Jethwa, P.H., Warner, A., Nilaweera, K.N., et al. VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters. Endocrinology 148(8), 4044-4055 (2007).

    4. Aguilar, E., Pineda, R., Gaytán, F., et al. Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: In vivo and in vitro studies. Neuroendocrinology 98(1), 38-50 (2013).