A peptide inhibitor of PANX1
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10Panx (trifluoroacetate salt)

Item No. 36867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine, trifluoroacetate salt
Synonyms
  • 10Panx1
  • WRQAAFVDSY
Molecular Formula
C58H79N15O16 • XCF3COOH
Formula Weight
1242.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C58H79N15O16.C2HF3O2/c1-29(2)47(56(87)70-42(26-46(77)78)53(84)72-44(28-74)55(86)71-43(57(88)89)24-33-16-18-35(75)19-17-33)73-54(85)41(23-32-11-6-5-7-12-32)69-49(80)31(4)65-48(79)30(3)66-51(82)40(20-21-45(60)76)68-52(83)39(15-10-22-63-58(61)62)67-50(81)37(59)25-34-27-64-38-14-9-8-13-36(34)38;3-2(4,5)1(6)7/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,79)(H,66,82)(H,67,81)(H,68,83)(H,69,80)(H,70,87)(H,71,86)(H,72,84)(H,73,85)(H,77,78)(H,88,89)(H4,61,62,63);(H,6,7)/t30-,31-,37-,39-,40-,41-,42-,43-,44-,47-;/m0./s1
InChi Key
IUVJNMNXJXOKNR-QLTCJPIHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $99

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    10 mg

    $181

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    25 mg

    $404

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    Product Description

    10Panx is a peptide mimetic of the pannexin 1 (PANX1) ectodomain and inhibitor of PANX1, an innexin family gap domain protein and component of membrane channels.1 It inhibits purinergic P2X7 receptor activation-induced dye uptake, constitutive dye uptake, and hemichannel currents, as well as ATP-induced caspase activation and IL-1β release in HEK293 cells when used at a concentration of 200 µM. 10Panx inhibits pannexin channel currents and connexin 46 channel currents in Xenopus oocytes expressing the human channels.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pelegrin, P., and Surprenant, A. Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor. EMBO J. 25(21), 5071-5082 (2006).

    2. Wang, J., Ma, M., Locovei, S., et al. Modulation of membrane channel currents by gap junction protein mimetic peptides: Size matters. Am. J. Physiol. Cell Physiol. 293(3), C1112-C1119 (2007).