A peptide AT2 receptor agonist
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Sarilesin (trifluoroacetate salt)

Item No. 36880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine, trifluoroacetate salt
Synonyms
  • Sarile
  • (Sar1, Ile8)-Angiotensin II
  • Xxe-Arg-Val-Tyr-Ile-His-Pro-Ile-OH (Xxe = sarcosyl)
Molecular Formula
C46H73N13O10 • XCF3COOH
Formula Weight
968.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
XRVYIHPI-OH (X = sarcosyl)
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O
InChi Code
InChI=1S/C46H73N13O10.C2HF3O2/c1-8-26(5)37(43(66)55-33(21-29-22-50-24-52-29)44(67)59-19-11-13-34(59)41(64)58-38(45(68)69)27(6)9-2)57-40(63)32(20-28-14-16-30(60)17-15-28)54-42(65)36(25(3)4)56-39(62)31(53-35(61)23-49-7)12-10-18-51-46(47)48;3-2(4,5)1(6)7/h14-17,22,24-27,31-34,36-38,49,60H,8-13,18-21,23H2,1-7H3,(H,50,52)(H,53,61)(H,54,65)(H,55,66)(H,56,62)(H,57,63)(H,58,64)(H,68,69)(H4,47,48,51);(H,6,7)/t26-,27-,31-,32-,33-,34-,36-,37-,38-;/m0./s1
InChi Key
CRMJFLJNJDPPTM-OFHYUQTQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $120

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    25 mg

    $266

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    50 mg

    $465

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    Product Description

    Sarilesin is a peptide angiotensin II type 2 (AT2) receptor agonist.1 It binds to AT2 receptors (Ki = 0.14 nM) and induces neurite outgrowth in NG108-15 cells when used at a concentration at 100 nM, an effect that can be inhibited by the AT2 receptor antagonist PD 123310. Intrathecal administration of sarilesin (1 µg/µl) increases mean arterial pressure and heart rate in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guimond, M.-O., Hallberg, M., Gallo-Payet, N., et al. Saralasin and sarile are AT2 receptor agonists. ACS Med. Chem. Lett. 5(10), 1129-1132 (2014).

    2. Yashpal, K., Gathier, S., and Henry, J.L. Angiotensin II stimulates sympathetic output by a direct spinal action. Neuropeptides 14(1), 21-29 (1989).