An antimicrobial cationic peptide
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Magainin 2 (trifluoroacetate salt)

Item No. 36900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-L-lysine-22-L-asparagine-magainin I, trifluoroacetate salt
Synonyms
  • MG2
Molecular Formula
C114H180N30O29S • XCF3COOH
Formula Weight
2466.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GIGKFLHSAKKFGKAFVGEIMNS-OH
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O=C(N[C@@](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)CC2=CC=CC=C2)=O)C)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O)=O)=O)([H])[C@@H](C)CC)CN[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C114H180N30O29S.C2HF3O2/c1-12-65(7)94(142-88(148)55-119)112(170)124-59-90(150)129-74(38-24-28-45-116)100(158)137-81(51-70-33-19-15-20-34-70)106(164)135-79(49-63(3)4)105(163)138-83(53-72-56-121-62-125-72)107(165)140-85(60-145)110(168)127-67(9)96(154)131-75(39-25-29-46-117)101(159)132-76(40-26-30-47-118)102(160)136-80(50-69-31-17-14-18-32-69)98(156)122-57-89(149)128-73(37-23-27-44-115)99(157)126-68(10)97(155)134-82(52-71-35-21-16-22-36-71)109(167)143-93(64(5)6)111(169)123-58-91(151)130-77(41-42-92(152)153)104(162)144-95(66(8)13-2)113(171)133-78(43-48-174-11)103(161)139-84(54-87(120)147)108(166)141-86(61-146)114(172)173;3-2(4,5)1(6)7/h14-22,31-36,56,62-68,73-86,93-95,145-146H,12-13,23-30,37-55,57-61,115-119H2,1-11H3,(H2,120,147)(H,121,125)(H,122,156)(H,123,169)(H,124,170)(H,126,157)(H,127,168)(H,128,149)(H,129,150)(H,130,151)(H,131,154)(H,132,159)(H,133,171)(H,134,155)(H,135,164)(H,136,160)(H,137,158)(H,138,163)(H,139,161)(H,140,165)(H,141,166)(H,142,148)(H,143,167)(H,144,162)(H,152,153)(H,172,173);(H,6,7)/t65-,66-,67-,68-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,93-,94-,95-;/m0./s1
InChi Key
HJBVHIURFJLLMD-KNPOGZCKSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Magainin 2 is a cationic peptide originally isolated from the skin of the African clawed frog (X. laevis) with roles in host defense and antimicrobial activity.1 It is active against the bacteria E. coli, K. pneumoniae, S. epidermidis, S. aureus, and the fungus C. albicans (MICs = 5, 10, 10, 50, and 80 µg/ml, respectively). Magainin 2 (20 µM) reduces germination percentage and mean tube elongation in kiwi fruit pollen.2 It decreases viral replication in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (EC50s = 22.16 and 19.8 µM, respectively) without affecting cell viability with a 50% cytotoxic concentration value (CC50) of greater than 100 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zasloff, M. Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA 84(15), 5449-5453 (1987).

    2. Speranza, A.M., Taddei, A.R., and Ovidi, E. In vitro toxicity towards kiwifruit pollen of the antimicrobial peptides magainins 1 and 2. Plant Biol. (Stuttg.) 9(6), 800-806 (2007).

    3. Albiol Matanic, V.C., and Castilla, V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int. J. Antimicrob. Agents 23(4), 382-389 (2004).