A Bak-derived peptide
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Bak BH3 (72-87) (human) (trifluoroacetate salt)

Item No. 36909

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-glutaminyl-L-valylglycyl-L-arginyl-L-glutaminyl-L-leucyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-α-aspartyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-arginine, trifluoroacetate salt
Molecular Formula
C72H125N25O24 • XCF3COOH
Formula Weight
1724.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C72H125N25O24.C2HF3O2/c1-12-34(8)55(67(117)84-31-51(103)88-44(27-52(104)105)64(114)92-45(28-53(106)107)65(115)96-56(35(9)13-2)68(118)93-43(26-48(76)100)63(113)90-41(70(120)121)18-16-24-82-72(79)80)97-69(119)57(36(10)14-3)95-58(108)37(11)85-62(112)42(25-32(4)5)91-60(110)40(20-22-47(75)99)89-59(109)38(17-15-23-81-71(77)78)87-50(102)30-83-66(116)54(33(6)7)94-61(111)39(19-21-46(74)98)86-49(101)29-73;3-2(4,5)1(6)7/h32-45,54-57H,12-31,73H2,1-11H3,(H2,74,98)(H2,75,99)(H2,76,100)(H,83,116)(H,84,117)(H,85,112)(H,86,101)(H,87,102)(H,88,103)(H,89,109)(H,90,113)(H,91,110)(H,92,114)(H,93,118)(H,94,111)(H,95,108)(H,96,115)(H,97,119)(H,104,105)(H,106,107)(H,120,121)(H4,77,78,81)(H4,79,80,82);(H,6,7)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,54-,55-,56-,57-;/m0./s1
InChi Key
OBFFIQXBYDGOBR-LOQUBTEHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Bak BH3 (72-87) is a peptide that corresponds to amino acids 72-87 of the pro-apoptotic protein Bak.1 It selectively binds to Bcl-xL over Bcl-2 (EC50s = 174 and 3,020 nM, respectively). Bak BH3 (72-87) induces apoptosis in LLC-PK1 porcine kidney epithelial cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frey, V., Viaud, J., Subra, G., et al. Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement. Eur. J. Med. Chem. 43(5), 966-972 (2008).

    2. Peherstorfer, E., Mayer, B., Boehm, S., et al. Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. Am. J. Physiol. Renal. Physiol. 283(1), F190-F196 (2002).