An antimicrobial peptide
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Pexiganan (acetate)

Item No. 36924

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide, acetate
CAS Number
172820-23-4
Synonyms
  • Cytolex
  • GIGKFLKKAKKFGKAFVKILKKa
  • GIGKFLKKAKKFGKAFVKILKK-NH2
  • MSI-78
Molecular Formula
C122H210N32O22 • XC2H4O2
Formula Weight
2477.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: 12 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
[H]NCCCC[C@H](NC(CNC([C@](NC(CN[H])=O)([H])[C@H](CC)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N)=O)=O)=O)CC(C)C)=O)([H])[C@H](CC)C)=O)=O)=O)CC1=CC=CC=C1)=O)C)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC3=CC=CC=C3)=O.CC(O)=O
InChi Code
InChI=1S/C122H210N32O22.C2H4O2/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123;1-2(3)4/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169);1H3,(H,3,4)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-;/m0./s1
InChi Key
ZYMCXUWEZQKVIO-IJAHCEAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Pexiganan is a synthetic antimicrobial peptide.1 It is active against various clinical isolates of bacteria from patients with diabetic foot infections, including S. aureus, methicillin-resistant S. aureus (MRSA), and P. aeruginosa (MICs = 16-32, 16-32, and 8-16 µg/ml, respectively). Pexiganan (1 mg/kg) decreases lethality in a mouse model of sepsis induced by A. baumannii.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Flamm, R.K., Rhomberg, P.R., Simpson, K.M., et al. In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms. Antimicrob. Agents Chemother. 59(3), 1751-1754 (2015).

    2. Cirioni, O., Simonetti, O., Pierpaoli, E., et al. Enhanced efficacy of combinations of pexiganan with colistin versus Acinetobacter Baumannii in experimental sepsis. Shock 46(2), 219-225 (2016).