An inhibitor of FOXM1 DNA-binding activity
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FOXM1 Inhibitor III

Item No. 36932

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-thieno[2,3-b]pyridine-2-carboxamide
CAS Number
313380-27-7
Synonyms
  • FDI-6
  • Forkhead Domain Inhibitory Compound 6
  • NCGC00099374
Molecular Formula
C19H11F4N3OS2
Formula Weight
437.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
285, 327, 354, 369, 410 nm
SMILES
O=C(C1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=CS3)N=C2S1)NC4=CC=C(C=C4)F
InChi Code
InChI=1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
InChi Key
ZATJMMZPGVDUOM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    FOXM1 inhibitor III is an inhibitor of the DNA-binding activity of forkhead box protein M1 (FOXM1; IC50 = 22.5 µM).1 It binds to FOXM1 and is selective for inhibiting FOXM1 transcriptional activity over FOXA1, FOXA2, FOXP2, and GATA-binding factor 1 (GATA-1) transcriptional activity. FOXM1 inhibitor III inhibits the growth of MCF-7 and MDA-MB-231 breast and PEO1 ovarian cancer cells (GI50s = 18, 21.8, and 18.1 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gormally, M.V., Dexheimer, T.S., Marsico, G., et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat. Commun. 5, 5165 (2014).