An ionizable cationic lipid
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ATX-100

Item No. 36935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-[[[[3-(dimethylamino)propyl]thio]carbonyl]imino]bis-butanoic acid, 1,1′-bis(1-heptyloctyl) ester
CAS Number
2230647-37-5
Synonyms
  • ATX-0126
  • ATX-126
  • Lipid 10p
Molecular Formula
C44H86N2O5S
Formula Weight
755.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in chloroform
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: SolubleWater: insolule
SMILES
O=C(N(CCCC(OC(CCCCCCC)CCCCCCC)=O)CCCC(OC(CCCCCCC)CCCCCCC)=O)SCCCN(C)C
InChi Code
InChI=1S/C44H86N2O5S/c1-7-11-15-19-23-30-40(31-24-20-16-12-8-2)50-42(47)34-27-37-46(44(49)52-39-29-36-45(5)6)38-28-35-43(48)51-41(32-25-21-17-13-9-3)33-26-22-18-14-10-4/h40-41H,7-39H2,1-6H3
InChi Key
HAWZMEVIHSUELL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $297

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    25 mg

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    Product Description

    ATX-100 is an ionizable cationic lipid (pKa = 6.38).1,2 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. Intravenous administration of LNPs containing ATX-100 and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rajappan, K., Tanis, S.P., Roberts, S., et al. Development of a safe and scalable process for the production of a high-purity thiocarbamate-based ionizable lipid as an excipient in mRNA-encapsulating lipid nanoparticles. Org. Process Res. Dev. 25(6), 1383-1390 (2021).

    2. Rajappan, K., Tanis, S.P., Mukthavaram, R., et al. Property-driven design and development of lipids for efficient delivery of siRNA. J. Med. Chem. 63(21), 12992-13012 (2020).