An inhibitor of the ubiquitin-proteasome system
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RAMB4

Item No. 36936

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-bis[(3,4-dichlorophenyl)methylene]-4-piperidinone
CAS Number
145888-79-5
Synonyms
  • NSC 638643
Molecular Formula
C19H13Cl4NO
Formula Weight
413.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
242, 329 nm
SMILES
O=C1C(CNCC1=CC2=CC=C(C(Cl)=C2)Cl)=CC3=CC=C(C(Cl)=C3)Cl
InChi Code
InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8,24H,9-10H2
InChi Key
GJPXGFGIFQWUOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $86

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    25 mg

    $172

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    50 mg

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    100 mg

    $429

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    Cayman Chemical
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    Product Description

    RAMB4 is an inhibitor of the ubiquitin-proteasome system.1 It increases the levels of polyubiquitinated proteins in HeLa cervical cancer cells, but does not inhibit the chymotrypsin-like, trypsin-like, or peptidylglutamyl peptide hydrolyzing-like activities of the 20S proteasome, in cell-free assays when used at a concentration of 10 µM. RAMB4 decreases the viability of HeLa cells (IC50 = 2 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anchoori, R.K., Khan, S.R., Sueblinvong, T., et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells. PLoS One 6(8), e23888 (2011).