A pan-serine hydrolase inhibitor
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AA26-8

Item No. 36937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-pyrrolidinyl-1H-1,2,3-triazol-1-yl-methanone
CAS Number
1312782-34-5
Synonyms
  • AA26-9
  • KK007-N1
Molecular Formula
C7H10N4O
Formula Weight
166.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
218 nm
SMILES
O=C(N1CCCC1)N2N=NC=C2
InChi Code
InChI=1S/C7H10N4O/c12-7(10-4-1-2-5-10)11-6-3-8-9-11/h3,6H,1-2,4-5H2
InChi Key
IFXGAMVQLDJRBQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $70

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    10 mg

    $131

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    25 mg

    $307

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    50 mg

    $544

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    Product Description

    AA26-8 is a pan-serine hydrolase inhibitor.1 It inhibits acylaminoacyl-peptide hydrolase (APEH), platelet-activating factor acetylhydrolase 2 (PAF-AH2), α/β hydrolase domain-containing protein 11 (ABHD11), lysophospholipase 1 (LYPLA1), fatty acid amide hydrolase (FAAH), and neutral cholesterol ester hydrolase 1 (NCEH1) when used at a concentration of 1 µM. AA26-8 (10 µM) also inhibits the interaction of the α/β hydrolase Dwarf14 (D14) and a negative regulator of its signaling, D53, induced by the plant growth regulator GR24 (Item No. 13210) in a yeast two-hybrid assay.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adibekian, A., Martin, B.R., Wang, C., et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat. Chem. Biol. 7(7), 469-478 (2011).

    2. Nakamura, H., Hirabayashi, K., Miyakawa, T., et al. Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responses. Mol. Plant 12(1), 44-58 (2019).