A cytokine synthesis inhibitor
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JTE-607

Item No. 36942

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine, ethyl ester, dihydrochloride
CAS Number
188791-09-5
Synonyms
  • TO-207
Molecular Formula
C25H31Cl2N3O5 • 2HCl
Formula Weight
597.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
216 nm
SMILES
CCOC([C@H](CC1=CC=CC=C1)NC(C2=C(C(Cl)=C(C(Cl)=C2)OCCN3CCN(CC3)C)O)=O)=O.Cl.Cl
InChi Code
InChI=1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1
InChi Key
JUJAUEQJEWIWCQ-FJSYBICCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    JTE-607 is an inhibitor of inflammatory cytokine synthesis.1 It inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively). JTE-607 binds to cleavage and polyadenylation-specific factor 3 (CPSF3), an enzyme involved in 3’-end processing of pre-mRNA, in cell-free assays and induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells.2 In vivo, JTE-607 (0.3-10 mg/kg, i.v.) reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kakutani, M., Takeuchi, K., Waga, I., et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm. Res. 48(8), 461-468 (1999).

    2. Kakegawa, J., Sakane, N., Suzuki, K., et al. JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing. Biochem. Biophys. Res. Commun. 518(1), 32-37 (2019).