An inhibitor of K2P18.1/TRESK
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A2764 (hydrochloride)

Item No. 36943

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(5-chloro-8-quinolinyl)oxy]-N,N-diethyl-ethanamine, dihydrochloride
CAS Number
861038-72-4
Molecular Formula
C15H19ClN2O • 2HCl
Formula Weight
351.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleEthanol: Slightly solublePBS (pH 7.2): 5 mg/ml
λmax
244 nm
SMILES
CCN(CC)CCOC1=CC=C(Cl)C2=C1N=CC=C2.Cl.Cl
InChi Code
InChI=1S/C15H19ClN2O.2ClH/c1-3-18(4-2)10-11-19-14-8-7-13(16)12-6-5-9-17-15(12)14;;/h5-9H,3-4,10-11H2,1-2H3;2*1H
InChi Key
ZVRDPULCSHGKBD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $33

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    50 mg

    $123

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    100 mg

    $227

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    250 mg

    $403

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    Product Description

    A2764 is an inhibitor of the two-pore domain potassium channel K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor).1 It is selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM. A2764 (100 µM) inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lengyel, M., Erdélyi, F., Pergel, E., et al. Chemically modified derivatives of the activator compound cloxyquin exert inhibitory effect on TRESK (K2P18.1) background potassium channel. Mol. Pharmacol. 95(6), 652-660 (2019).