An antimicrobial peptide
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Cathelicidin-2 (128-153) (chicken) (trifluoroacetate salt)

Item No. 36947

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-phenylalanylglycyl-L-arginyl-L-phenylalanyl-L-leucyl-L-lysyl-L-isoleucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-arginyl-L-prolyl-L-lysyl-L-valyl-L-threonyl-L-isoleucyl-L-threonyl-L-isoleucyl-L-glutaminylglycyl-L-seryl-L-alanyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt
Synonyms
  • CATH-2 (128-153)
  • Fowlicidin-2 (128-153)
  • Myeloid Antimicrobial Peptide 27 (128-153)
Molecular Formula
C147H245N51O30 • XCF3COOH
Formula Weight
3206.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
RFGRFLRKIRRFRPKVTITIQGSARF-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)N[H])=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)([H])[C@H](CC)C)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C147H245N51O30.C2HF3O2/c1-14-81(8)112(193-128(216)93(50-29-31-61-148)180-123(211)96(54-36-66-170-144(159)160)182-129(217)102(71-79(4)5)189-131(219)105(75-90-47-27-20-28-48-90)190-122(210)92(52-34-64-168-142(155)156)177-109(203)76-175-121(209)103(73-88-43-23-18-24-44-88)188-119(207)91(150)49-33-63-167-141(153)154)135(223)184-98(56-38-68-172-146(163)164)124(212)181-97(55-37-67-171-145(161)162)126(214)191-104(74-89-45-25-19-26-46-89)130(218)186-100(57-39-69-173-147(165)166)140(228)198-70-40-58-107(198)133(221)183-94(51-30-32-62-149)127(215)192-111(80(6)7)134(222)196-115(85(12)200)138(226)195-114(83(10)16-3)137(225)197-116(86(13)201)139(227)194-113(82(9)15-2)136(224)185-99(59-60-108(151)202)120(208)174-77-110(204)178-106(78-199)132(220)176-84(11)118(206)179-95(53-35-65-169-143(157)158)125(213)187-101(117(152)205)72-87-41-21-17-22-42-87;3-2(4,5)1(6)7/h17-28,41-48,79-86,91-107,111-116,199-201H,14-16,29-40,49-78,148-150H2,1-13H3,(H2,151,202)(H2,152,205)(H,174,208)(H,175,209)(H,176,220)(H,177,203)(H,178,204)(H,179,206)(H,180,211)(H,181,212)(H,182,217)(H,183,221)(H,184,223)(H,185,224)(H,186,218)(H,187,213)(H,188,207)(H,189,219)(H,190,210)(H,191,214)(H,192,215)(H,193,216)(H,194,227)(H,195,226)(H,196,222)(H,197,225)(H4,153,154,167)(H4,155,156,168)(H4,157,158,169)(H4,159,160,170)(H4,161,162,171)(H4,163,164,172)(H4,165,166,173);(H,6,7)/t81-,82-,83-,84-,85+,86+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,111-,112-,113-,114-,115-,116-;/m0./s1
InChi Key
JJMXLAGJLKSTEX-IDVPIXFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide that corresponds to amino acids 128-153 of chicken CATH-2.1 It is active against E. coli, S. aureus, S. enteritidis, and B. globigii in a concentration-dependent manner. CATH-2 (128-153) (40 µM) induces hemolysis of isolated chicken erythrocytes but is not cytotoxic to isolated human peripheral blood mononuclear cells (PBMCs). It induces production of chemokine (C-C-motif) ligand 2 (CCL2) and inhibits LPS-induced production of TNF-α, IL-6, IL-8, and IL-10 in isolated human PBMCs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Dijk, A., Molhoek, E.M., Veldhuizen, E.J.A., et al. Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities. Mol. Immunol. 46(13), 2465-2473 (2009).